{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:27:22Z","timestamp":1774020442925,"version":"3.50.1"},"reference-count":113,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This literature review explores the terminology, the neurophysiology, and the assessment of cough in general, in the framework of dysphagia and regarding head and neck cancer patients at risk for dysphagia. In the dysphagic population, cough is currently assessed perceptually during a clinical swallowing evaluation or aerodynamically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Recent findings<\/jats:title><jats:p>Recent findings have shown intra and inter\u2010rater disagreements regarding perceptual scoring of cough. Also, aerodynamic measurements are impractical in a routine bedside assessment. Coughing, however, is considered to be a clinically relevant sign of aspiration and dysphagia in head and cancer patients treated with concurrent chemoradiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This article surveys the literature regarding the established cough assessment and stresses the need to implement innovative methods for assessing cough in head and neck cancer patients treated with concurrent chemoradiotherapy at risk for dysphagia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1395","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T09:57:55Z","timestamp":1619863075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of cough in head and neck cancer patients at risk for dysphagia\u2014An overview"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4917-7360","authenticated-orcid":false,"given":"Sofiana","family":"Mootassim\u2010Billah","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Speech Therapy, Institut Jules Bordet Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwen","family":"Van Nuffelen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, University Rehabilitation Center for Communication Disorders Antwerp University Hospital  Antwerp Belgium"},{"name":"Department of Translational Neurosciences, Faculty of Medicine and Health Sciences University of Antwerp  Antwerp Belgium"},{"name":"Department of Logopaedics and Audiological Sciences, Faculty of Medicine and Health Sciences University of Ghent  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Schoentgen","sequence":"additional","affiliation":[{"name":"BEAMS (Bio\u2010, Electro\u2010 And Mechanical Systems) Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"De Bodt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, University Rehabilitation Center for Communication Disorders Antwerp University Hospital  Antwerp Belgium"},{"name":"Department of Translational Neurosciences, Faculty of Medicine and Health Sciences University of Antwerp  Antwerp Belgium"},{"name":"Department of Logopaedics and Audiological Sciences, Faculty of Medicine and Health Sciences University of Ghent  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Dragan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Head and Neck Unit, Institut Jules Bordet Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Digonnet","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Head and Neck Surgery Unit, Institut Jules Bordet Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Roper","sequence":"additional","affiliation":[{"name":"Department of Oto\u2010Rhino\u2010Laryngology and Head &amp; Neck Surgery, Erasme Hospital Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Van Gestel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Head and Neck Unit, Institut Jules Bordet Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.05.003"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.0079"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40141-016-0134-5"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3680-z"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1395790"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3379-6"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.6647"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9016-z"},{"key":"e_1_2_14_10_1","first-page":"35","article-title":"Cough and aspiration of food and liquids due to oral pharyngeal","volume":"186","author":"Hammond CS","year":"2008","journal-title":"Dysphagia"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-015-9605-6"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417897"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2014.38.4.476"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(01)00429-7"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9710-1"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.01.019"},{"issue":"14","key":"e_1_2_14_17_1","first-page":"149","article-title":"Effects of thorax irradiation on citric\u2010acid induced cough Guinea pigs","volume":"57","author":"Javorkova N","year":"2006","journal-title":"J Physiol Pharmacol"},{"issue":"15","key":"e_1_2_14_18_1","first-page":"67","article-title":"Influence of chest gamma\u2010irradiation pn cough response in awake Guinea pigs","volume":"58","author":"Brozmanova M","year":"2007","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00118-4"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.05.050"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-013-9500-y"},{"key":"e_1_2_14_22_1","first-page":"302","article-title":"Aspiration rate following chemoradiation for head and neck cancer: an underreported occurrence","volume":"80","author":"Nguyen NP","year":"2006","journal-title":"Head Neck Radiother"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2211-6"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/2454-6798.165109"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24296"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29207"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27631"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2013.05.003"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.09.002"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0008"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.050"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23275"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-019-00912-x"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21627"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.742205"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-017-9847-6"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.07.042"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-010-9285-1"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1628-5"},{"key":"e_1_2_14_40_1","volume-title":"Chronic Cough","author":"Carroll TL","year":"2019"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2019.60.12.1181"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2313"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-002-0054-7"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9708-8"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00007.2002"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.01.002"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00101006"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-017-9996-2"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-010-9282-4"},{"key":"e_1_2_14_50_1","volume-title":"Speech Pathology Management of Chronic Refractory Cough and Related Disorders","author":"Vertigan AE","year":"2016"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9734-6"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00096905"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2008.11.003"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9045-7"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40141-018-0202-0"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1954.sp005034"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1481"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-9-7"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4597-10.2011"},{"issue":"5","key":"e_1_2_14_60_1","first-page":"1","article-title":"Anatomy and neuro\u2010pathophysiology of the cough reflex arc","volume":"7","author":"Polverino M","year":"2012","journal-title":"Multidiscip Respir Med"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.057901"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-7-11"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-010-9272-1"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6121.1000240"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.09.013"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1179\/2050572814Y.0000000041"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.09.013"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-018-0625-z"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.09.010"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.213157"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00167"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.029"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-3692(15)51851-5"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.067413"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compag.2008.07.003"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2010.06.013"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9059-1"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2006.11.009"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217366"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9845321"},{"key":"e_1_2_14_81_1","doi-asserted-by":"crossref","unstructured":"ChatrzarrinH.Feature Extraction for the Differentiation of Dry and Wet Cough Sounds. Carleton University;2011.","DOI":"10.1109\/MeMeA.2011.5966670"},{"key":"e_1_2_14_82_1","unstructured":"XavieroR PramonoA ImtiazSA Rodriguez\u2010villegasE.Automatic identification of cough events from acoustic signals. Paper presented at: 2019 41st Annu Int Conf IEEE Eng Med Biol Soc.2019;217\u201020."},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S154539"},{"key":"e_1_2_14_84_1","doi-asserted-by":"crossref","unstructured":"MirandaIDS DiaconAH NieslerTR.A comparative study of features for acoustic cough detection using deep architectures. Paper presented at: 2019 41st Annu Int Conf IEEE Eng Med Biol Soc.2019;2601\u20102605.","DOI":"10.1109\/EMBC.2019.8856412"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-2-1"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2020.0944"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.3109\/17549507.2012.692812"},{"issue":"2","key":"e_1_2_14_88_1","first-page":"225","article-title":"Swallowing disorders after treatment for head and neck cancer","volume":"53","author":"Pezdirec M","year":"2019","journal-title":"Radiat Oncol Biol"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004550010002"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004550010005"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2009\/08-0246)"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-011-9334-z"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2018.1510011"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0342"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1122"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.06.015"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.05.004"},{"key":"e_1_2_14_98_1","doi-asserted-by":"crossref","unstructured":"SejdicE DudikJM KurosuA JestrovicI CoyleJL.Understanding differences between healthy swallows and penetration\u2010aspiration swallows via compressive sensing of tri\u2010axial swallowing accelerometry signals. Paper presented at: Proc SPIE Compressive Sens III.2014;9109:91090M\u20131\u201091090M\u20136.","DOI":"10.1117\/12.2050356"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-016-9727-5"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12984-015-0110-9"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1109\/JTEHM.2015.2500562"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1109\/THMS.2015.2408615"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-016-1561-2"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-007-9078-3"},{"issue":"3","key":"e_1_2_14_105_1","first-page":"1","article-title":"A comparative analysis of swallowing accelerometry and sounds during saliva swallows","volume":"14","author":"Dudik JM","year":"2015","journal-title":"Biomed Eng Online"},{"issue":"377","key":"e_1_2_14_106_1","first-page":"1","article-title":"Cervical auscultation in the diagnosis of oropharyngeal aspiration in children: a study protocol for a randomised controlled trial","volume":"14","author":"Frakking TT","year":"2013","journal-title":"Trials"},{"key":"e_1_2_14_107_1","doi-asserted-by":"crossref","unstructured":"MovahediF KurosuA CoyleJL PereraS SejdicE.A comparison between swallowing sounds and vibrations in patients with dysphagia.2017;144:179\u2010187.","DOI":"10.1016\/j.cmpb.2017.03.009"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-007-9084-5"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215502cr533oa"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.89"},{"issue":"4","key":"e_1_2_14_111_1","first-page":"231","article-title":"Reliability and validity of cervical auscultation: a controlled comparison using videofluoroscopy","volume":"19","author":"Leslie P","year":"2004","journal-title":"Dysphagia"},{"issue":"2782","key":"e_1_2_14_112_1","first-page":"1","article-title":"Clinical significance of cough peak flow and its non\u2010contact measurement via cough sounds","volume":"10","author":"Umayahara Y","year":"2020","journal-title":"Appl Sci"},{"issue":"3810","key":"e_1_2_14_113_1","first-page":"1","article-title":"A mobile cough strength evaluation device using cough sounds","volume":"18","author":"Umayahara Y","year":"2018","journal-title":"Sensors"},{"issue":"2381","key":"e_1_2_14_114_1","first-page":"1","article-title":"Estimation of cough peak flow using cough sounds","volume":"18","author":"Umayahara Y","year":"2018","journal-title":"Sensors"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1395","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:17:04Z","timestamp":1693199824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":113,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/cnr2.1395"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1395","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"2020-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1395"}}