{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:18:16Z","timestamp":1788394696381,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between patient self\u2010reported pain severity and health\u2010related quality\u2010of\u2010life (HRQoL) is poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This real\u2010world study of symptomatic multiple myeloma (MM) patients sought to determine how pain severity from a single question asked during routine clinical consultation was associated with HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Point\u2010in\u2010time data on HRQoL of 330 patients with MM (median age 70\u2009years) receiving anti\u2010myeloma therapy in Germany and Italy from November 2017 through February 2018 were analyzed. HRQoL was assessed using validated questionnaires (Work Productivity and Activity Impairment [WPAI], European Organization for Research and Treatment of Cancer Quality of Life Questionnaire \u2010C30 and \u2010MY20). Physical pain severity was assessed during clinical consultation by a single question, asking patients to describe their pain as \u201cno pain,\u201d \u201cmild,\u201d \u201cmoderate,\u201d or \u201csevere.\u201d Associations between patient\u2010reported pain severity and HRQoL scores were assessed by analysis of variance or <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> tests. Ninety\u2010six of the 330 patients (29.1%) reported moderate to severe pain. Increase in pain severity, from \u201cno\u201d to \u201csevere\u201d pain, was associated with significantly decreased overall HRQoL (mean score 70.2 to 33.3); significant decreases in levels of physical (82.7 to 35.1), social (81.1 to 44.4), emotional (78.1 to 48.3), and role functioning (79.5 to 38.9); and increased levels of WPAI usual activity impairment (35.4 to 71.4), and fatigue burden (26.0 to 68.9) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher pain severity, based on a single self\u2010report question, was associated with poorer HRQoL in patients with MM, thereby supporting the clinical relevance of directly asking patients to self\u2010evaluate their pain severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1429","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T23:06:28Z","timestamp":1623366388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Patient\u2010reported pain severity and health\u2010related quality of life in patients with multiple myeloma in real world clinical practice"],"prefix":"10.1002","volume":"5","author":[{"given":"Heinz","family":"Ludwig","sequence":"first","affiliation":[{"name":"Medical Department Center for Oncology, Hematology and Palliative Medicine Wilhelminen Cancer Research Institute  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0238-6723","authenticated-orcid":false,"given":"Abigail Lucy","family":"Bailey","sequence":"additional","affiliation":[{"name":"Oncology Adelphi Real World, Adelphi Mill  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marongiu","sequence":"additional","affiliation":[{"name":"Centre for Observational Research Amgen Ltd  Uxbridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerun","family":"Khela","sequence":"additional","affiliation":[{"name":"Oncology Adelphi Real World, Adelphi Mill  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Milligan","sequence":"additional","affiliation":[{"name":"Oncology Adelphi Real World, Adelphi Mill  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine Brewer","family":"Carlson","sequence":"additional","affiliation":[{"name":"Center for Observational Research Amgen Inc  Thousand Oaks California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Rider","sequence":"additional","affiliation":[{"name":"Oncology Adelphi Real World, Adelphi Mill  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouchka","family":"Seesaghur","sequence":"additional","affiliation":[{"name":"Centre for Observational Research Amgen Ltd  Uxbridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy152"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1666381"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11122037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12790"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7748\/cnp.2017.e1450"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.0383"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2019.1645005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-008-9379-5"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"44","article-title":"The challenges of cancer pain assessment","volume":"83","author":"Stewart J","year":"2014","journal-title":"Ulster Med J"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802457040"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(96)00822-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.04.022"},{"key":"e_1_2_10_14_1","unstructured":"FayersPM AaronsonNK BjordalK GroenvoldM CurranD BottomleyA on behalf of the EORTC Quality of Life Group. 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