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Quality of life and psychosocial measures included the Functional Assessment of Cancer Therapy\u2010General, Distress Thermometer (distress), Patient Health Questionnaire\u20108 (depression), General Anxiety Disorder\u20107 (anxiety), and Post\u2010traumatic Stress Disorder Checklist for DSM\u20105 (post\u2010traumatic stress disorder; PTSD). Measures were compared by self\u2010reported sexual orientation (heterosexual vs. LGB) using descriptive statistics (frequencies and means) and linear and logistic regression models, adjusting for college education.<\/jats:p><jats:p>Of 814 patients invited, 457 enrolled (56.1%) and 401 (92.6%) completed the survey and provided information on their sexuality. All but one self\u2010identified as cisgender women and 22 (5.5%) as LGB. LGB participants were more likely to have completed college (68.2% vs. 40.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009) but were otherwise similar across demographic and clinical characteristics. Quality of life and distress scores were similar between groups. LGB participants, compared to heterosexual, reported higher rates of depression (31.8% vs. 10.6%, adjusted odds ratio [OR]\u00a0=\u00a04.1 [95% confidence interval [CI]: 1.6\u201311.0], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004), anxiety (25.0% vs. 7.1%, adjusted OR\u00a0=\u00a05.4 [95% CI: 1.7\u201316.7], <jats:italic>p<\/jats:italic>=\u2009.004), and PTSD (13.6% vs. 3.5%, adjusted OR\u00a0=\u00a04.2 [95% CI: 1.1\u201316.3], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LGB participants reported poorer emotional health following a gynecologic cancer diagnosis than heterosexual participants. Our data suggest this population may need additional resources and support during and after their cancer diagnosis. Future work is needed to identify additional risk factors and the underlying sources of these disparities in order to improve patient care and wellness in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1461","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T09:12:27Z","timestamp":1622452347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cross\u2010sectional study of psychosocial well\u2010being among lesbian, gay, bisexual, and heterosexual gynecologic cancer\u2009survivors"],"prefix":"10.1002","volume":"5","author":[{"given":"Alexandra","family":"Schefter","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Division of Gynecologic Oncology Gynecology and Women's Health, University of Minnesota  Minneapolis Minnesota 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