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Complete population\u2010representative cohorts with long\u2010term follow\u2010up are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate factors of importance for the long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>An Observational population\u2010based study on consecutive GEP\u2010NEN patients diagnosed from 2003 to 2013, managed according to national guidelines. Univariable and multivariable survival analyses were performed to evaluate overall survival (OS) and to identify independent prognostic factors. One hundred ninety eligible patients (males, 58.9%) (median age, 60.0\u2009years; range, 10.0\u201394.2\u2009years) were included. The small bowel, appendix, and pancreas were the most common tumor locations. The World Health Organization (WHO) tumor grade 1\u20133 distributions varied according to the primary location and disease stage. Primary surgery with curative intent was performed in 66% of the patients. The median OS of the study population was 183\u2009months with 5\u2010 and 10\u2010year OS rates of 66% and 57%, respectively. Only age, WHO tumor grade, and primary surgical treatment were independent prognostic factors for OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The outcomes of GEP\u2010NEN patients are related to several factors including age and primary surgical treatment. WHO tumor grading, based on the established criteria, should be routine in clinical practice. This may improve clinical decision\u2010making and allow the comparison of outcomes among different centers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1462","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T12:10:22Z","timestamp":1623240622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The overriding role of surgery and tumor grade for long\u2010term survival in patients with gastroenteropancreatic neuroendocrine neoplasms: A population\u2010based cohort study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7572-1089","authenticated-orcid":false,"given":"Jon Arne","family":"S\u00f8reide","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Terje","family":"Kval\u00f8y","sequence":"additional","affiliation":[{"name":"Department of Research Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Mathematics and Physics University of Stavanger  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dordi","family":"Lea","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"Department of Pathology Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oddvar M.","family":"Sandvik","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Al\u2010Saiddi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torjan M.","family":"Haslerud","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herish","family":"Garresori","sequence":"additional","affiliation":[{"name":"Department of Oncology Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars N.","family":"Karlsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einar","family":"Gudlaugsson","sequence":"additional","affiliation":[{"name":"Department of Pathology Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjetil","family":"S\u00f8reide","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Stavanger University Hospital  Stavanger Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0739-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20097"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21493"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10034"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2018.1553061"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.12.017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31137"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1598"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010236"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.214882"},{"volume-title":"TNM Classification of Malignant Tumours","year":"2009","author":"Sobin LH","key":"e_1_2_10_13_1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000225949"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000184855"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2010.492791"},{"key":"e_1_2_10_19_1","unstructured":"Collaborative.Neuroendokrine tumorer. 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