{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T03:09:56Z","timestamp":1785726596971,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013779","name":"Sabzevar University of Medical Sciences","doi-asserted-by":"publisher","award":["99302"],"award-info":[{"award-number":["99302"]}],"id":[{"id":"10.13039\/501100013779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prostate cancer is the most prevalent cancer in men. However, leptomeningeal involvement by prostate carcinoma is a rare event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>Here, we report a 69\u2010year\u2010old patient with castration\u2010resistant metastatic prostate cancer who presented with headache and ataxia. Brain MRI revealed a huge invasive interaxial mass at right occipital lobe with diffuse thickening and enhancement of meninges, the arachnoid, and the pia mater, and he was diagnosed with leptomeningeal carcinomatosis. The patient received whole brain radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the fact that brain and leptomeningeal metastases are not very common in patients with prostate cancer, signs and symptoms of nervous system disorders should be assessed carefully, and consideration of such unusual metastases must be considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1463","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T11:33:10Z","timestamp":1622892790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A case report of prostate cancer with leptomeningeal metastasis"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-8525","authenticated-orcid":false,"given":"Mansoureh","family":"Dehghani","sequence":"first","affiliation":[{"name":"Cancer Research Centre Mashhad University of Medical 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Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fateme","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-6412","authenticated-orcid":false,"given":"James S.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Edward Hines Jr VA Hospital and Loyola University Chicago Stritch School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-837X","authenticated-orcid":false,"given":"Seyed Alireza","family":"Javadinia","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Sabzevar University of Medical Sciences  Sabzevar 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