{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:45:28Z","timestamp":1775555128383,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cyclin\u2010dependent kinase (CDK) 4\/6 inhibitors have recently been approved for the treatment of hormone receptor\u2013positive and HER2\u2010negative metastatic breast cancer in association with endocrine therapy in postmenopausal women. Data on the interaction of CDK4\/6 inhibition and radiotherapy are scarce, but some studies show unexpected toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Cases<\/jats:title><jats:p>We report three cases of unexpected severe or prolonged soft tissue, skin, and gastrointestinal toxicity in patients treated with a combination of radiotherapy and the CDK4\/6 inhibitor palbociclib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These cases indicate a possible interaction between radiotherapy and palbociclib. Therefore, we recommend using radiotherapy cautiously when combined with CDK4\/6 inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1470","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T10:41:53Z","timestamp":1624012913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Unexpected toxicity of <scp>CDK4<\/scp>\/6 inhibitor palbociclib and radiotherapy"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2358-4435","authenticated-orcid":false,"given":"Evert S. 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