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We hypothesized that racial and ethnic minority patients would report greater symptom burden than non\u2010Hispanic and White patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A total of 5798 cancer patients completed the Edmonton Symptom Assessment Scale\u2014revised (ESAS\u2010r\u2010CSS) at least once as part of clinical care. Two indicators of symptom burden were evaluated: (1) total ESAS\u2010r\u2010CSS score (i.e., overall symptom burden) and (2) number of severe symptoms (i.e., severe symptomatology). For patients completing the ESAS\u2010r\u2010CSS on multiple occasions, the highest score for each indicator was used. Zero\u2010inflated negative binomial regression analyses were conducted, adjusting for other sociodemographic and clinical characteristics. Symptomology varied across race. Patients who self\u2010identified as Black reported higher symptom burden (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.016) and were more likely to report severe symptoms (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) than self\u2010identified White patients. Patients with \u201cother\u201d race were also more likely to report severe symptoms than White patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.032), but reported similar total symptom burden (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.315). Asian and Hispanic patients did not differ from White or non\u2010Hispanic patients on symptom burden (<jats:italic>p<\/jats:italic>s\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study describes racial disparities in patient\u2010reported symptom burden during routine oncology care, primarily observed in Black patients. Clinic\u2010based electronic symptom monitoring may be useful to detect high symptom burden, particularly in patients who self\u2010identify their race as Black or other. Future research is needed to reduce symptom burden in racially diverse cancer populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1478","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T10:40:23Z","timestamp":1624531223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<scp>Patient\u2010reported<\/scp> symptom burden in routine oncology care: Examining racial and ethnic disparities"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-0303","authenticated-orcid":false,"given":"Hailey W.","family":"Bulls","sequence":"first","affiliation":[{"name":"Department of Health Outcomes and Behavior Moffitt Cancer Center  Tampa Florida USA"},{"name":"Division of General Internal Medicine, Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi\u2010Hua","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Nursing Taichung Veterans General Hospital  Taichung Taiwan, ROC"},{"name":"School of Nursing College of Medicine, National Taiwan University  Taipei Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9991-427X","authenticated-orcid":false,"given":"Naomi C.","family":"Brownstein","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Moffitt Cancer Center  Tampa Florida USA"},{"name":"Department of Radiation Oncology Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8691-8132","authenticated-orcid":false,"given":"Aasha I.","family":"Hoogland","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-3711","authenticated-orcid":false,"given":"Heather S. 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