{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:07:23Z","timestamp":1773241643322,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Secretory carcinoma is a more recently described subtype of salivary gland carcinoma that may pose diagnostic challenges and frequently harbors <jats:italic>NTRK<\/jats:italic> fusions that may successfully be targeted by TRK inhibitors in advanced disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We present the case of a female patient with secretory carcinoma arising in the base of tongue with persistent disease after debulking surgery and definitive chemoradiation. As an alternative to salvage surgery, which would have resulted in significant impairment of swallowing and speech function, a targeted therapy with the TRK\u2010inhibitor larotrectinib against an identified <jats:italic>ETV6\u2010NTRK3<\/jats:italic> fusion product was initiated. Larotrectinib treatment has been well tolerated, resulted in durable complete response and the patient maintains good swallowing and speech function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presented case underscores the importance of the accurate diagnosis of secretory carcinoma. It further highlights the impact of molecular testing as targeted therapies may play an important role in the management of advanced salivary gland cancers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1491","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T08:21:13Z","timestamp":1625646073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic challenges and successful organ\u2010preserving therapy in a case of secretory carcinoma of minor salivary glands"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-2531","authenticated-orcid":false,"given":"Ruben","family":"Bill","sequence":"first","affiliation":[{"name":"Center for Systems Biology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G.","family":"Deschler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael J.","family":"Pittet","sequence":"additional","affiliation":[{"name":"Center for Systems Biology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Pathology and Immunology University of Geneva  Geneva Switzerland"},{"name":"Department of Oncology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara I.","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Surgery, Division of Oncologic Surgery Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Sadow","sequence":"additional","affiliation":[{"name":"Departments of Pathology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1052-0734","authenticated-orcid":false,"given":"Jong Chul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d9efcc"},{"key":"e_1_2_9_3_1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Naggar 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