{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:52:43Z","timestamp":1760953963570,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA131333"],"award-info":[{"award-number":["R01 CA131333"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2 TR002015","UL1 TR000003","UL1 TR002014"],"award-info":[{"award-number":["KL2 TR002015","UL1 TR000003","UL1 TR002014"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Excess adiposity and dysregulated metabolism are associated with increased cancer risk. Triglycerides, cholesterol, glucose, insulin, HOMA\u2010IR, and VO<jats:sub>2<\/jats:sub>max are robust clinical\u2010metabolic biomarkers of overall health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Aerobic exercise may improve clinical\u2010metabolic biomarkers and decrease cancer risk. This secondary analysis of the WISER Sister randomized controlled trial investigated dose\u2010dependent effects of aerobic exercise on clinical biomarker levels in women at high genetic risk for breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>One hundred thirty\u2010nine participants were randomized to: control (&lt;75\u2009min\/week), low\u2010dose (150\u2009min\/week), and high\u2010dose (300\u2009min\/week) aerobic exercise intervention groups. Intervention adherence was assessed via heart monitor. Fasting blood draws, cardio\u2010pulmonary tests, and demographical surveys were taken at baseline and 5 months. Triglyceride, cholesterol, glucose, insulin, and VO<jats:sub>2<\/jats:sub>max changes were assessed for 80 of the 122 study completers. Ninety\u2010six percent of assayed\u2010completers adhered to &gt;80% of their exercise dose. A significant dose\u2010dependent increase in VO<jats:sub>2<\/jats:sub>max was observed for the low\u2010dose and high\u2010dose groups compared to control. No intervention effects were observed for plasma biomarkers. Overweight women (BMI\u2009&gt;\u200925) showed a significant decrease in insulin levels and a trend for decreased triglycerides following exercise intervention. Significant increases in VO<jats:sub>2<\/jats:sub>max were independent of BMI stratification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women at high genetic risk for breast cancer should maintain healthy weights and aerobic capacities through aerobic exercise to achieve measurable benefits on overall health. For overweight women, exercise appears to improve subclinical metabolic dysregulation. However, normal weight women were unaffected by aerobic exercise as their biomarker levels may be below the threshold for improvement. VO<jats:sub>2<\/jats:sub>max increases solely quantified the benefits of exercise in already healthy women at high\u2010risk for breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1497","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T11:39:17Z","timestamp":1625830757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dose\u2010dependent effects of aerobic exercise on clinically relevant biomarkers among healthy women at high genetic risk for breast cancer: A secondary analysis of a randomized controlled study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-4563","authenticated-orcid":false,"given":"Christopher J.","family":"Ehret","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences, College of Medicine Pennsylvania State University  Hershey Pennsylvania 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