{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:08:59Z","timestamp":1787724539444,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A metastatic lesion located in the ampulla of Vater is considered extremely rare, with only 32 cases reported globally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 65\u2010year\u2010old patient was primarily diagnosed with a rectal adenocarcinoma. Twenty\u2010four months later as part of the oncological follow\u2010up, the patient was diagnosed with a single secondary tumor in the ampulla of Vater. After undergoing a pancreaticoduodenectomy (Whipple procedure), the patient experienced an uneventful recovery and received adjuvant chemotherapy. Sixteen months later the patient remained disease\u2010free.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To the best of our knowledge, the present case represents the first reported metastatic tumor in the ampulla of Vater, originating from a rectal adenocarcinoma. This case underlines the critical role of immunohistochemistry in arriving at a correct diagnosis in order to guide clinical decision\u2010making.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1510","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T08:33:08Z","timestamp":1626510788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metastatic rectal cancer in the ampulla of Vater: A unique case"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-7281","authenticated-orcid":false,"given":"Athina A.","family":"Samara","sequence":"first","affiliation":[{"name":"Department of Surgery University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna\u2010Konstantina","family":"Sgantzou","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Diamantis","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Kokkalis","sequence":"additional","affiliation":[{"name":"Department of Oncology University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Tsapakidis","sequence":"additional","affiliation":[{"name":"Department of Oncology University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tolia","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Christodoulidis","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Rountas","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Zacharoulis","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2014.1756"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317592"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.72.1464"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2017.1374"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2014.02.003"},{"issue":"2","key":"e_1_2_9_8_1","first-page":"274","article-title":"Secondary tumours of the ampulla of Vater: case report and review of the literature","volume":"8","author":"Sarocchi F","year":"2018","journal-title":"Mol Clin Oncol"},{"key":"e_1_2_9_9_1","unstructured":"National Comprehensive Cancer Network guidelines.National Comprehensive Cancer Network guidelines.https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1461. 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