{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:15:05Z","timestamp":1777536905031,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mulibrey\u2010Nanism (<jats:italic>Mu<\/jats:italic>scle\u2010<jats:italic>li<\/jats:italic>ver\u2010<jats:italic>br<\/jats:italic>ain\u2010<jats:italic>e<\/jats:italic>ye Nanism\u00a0=\u00a0dwarfism; MUL) is a rare genetic syndrome. The underlying TRIM37 mutation predisposes these children to develop tumors frequently. In the largest published series of MUL, 8% patients were reported to develop Wilms tumor (WT). The published literature lacks data regarding the best treatment protocol and outcome of this cohort of children with WT and MUL. We report here a 2\u2010year\u2010old boy with WT and MUL and present a review of literature on WT in MUL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>Our patient had associated cardiac problems of atrial septal defect, atrial flutter and an episode of sudden cardiac arrest. We managed him successfully with chemotherapy, surgery and multi\u2010speciality care. He is alive and in remission at follow\u2010up of 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A total of 14 cases (including present case) of WT have been reported in MUL and treatment details were available for six cases. They were managed primarily with surgery, chemotherapy with\/without radiotherapy, and all achieved remission. The outcome data is available only for two cases, one has been followed up till 15\u2009years post treatment for WT and other is our patient.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1512","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T10:19:48Z","timestamp":1627294788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Wilms tumor with Mulibrey Nanism: A case report and review of literature"],"prefix":"10.1002","volume":"5","author":[{"given":"Karthik","family":"Upasana","sequence":"first","affiliation":[{"name":"Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute Medanta The Medicity Hospital  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhwanee","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute Medanta The Medicity Hospital  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheeraj","family":"Gautam","sequence":"additional","affiliation":[{"name":"Department of Pathology Medanta The Medicity  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manvinder Singh","family":"Sachdev","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Medanta The Medicity  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Yadav","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute Medanta The Medicity Hospital  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute Medanta The Medicity Hospital  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Raghunathan","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Department of Pediatrics Medanta The Medicity  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maninder Singh","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Department of Pediatrics Medanta The Medicity  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartikeya","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology and Pacing, Heart Institute Medanta The Medicity  Gurgaon Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhya","family":"Nair","sequence":"additional","affiliation":[{"name":"MedGenome Labs Ltd.  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