{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:19:13Z","timestamp":1788484753877,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u2010102613"],"award-info":[{"award-number":["MOP\u2010102613"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the increasing trend of cutaneous malignant melanoma (CMM) incidence in Canada, especially among females, few risk factors other than ultraviolet radiation exposure, have been identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We conducted a case\u2013control study of 406 CMM cases and 181 controls to evaluate the potential impact of body burdens of various persistent organic pollutants on CMM risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Detailed data on potential confounding factors, including lifetime repeated sun exposure and skin reaction to repeated sun exposure, were collected. Gas chromatography tandem mass spectrometry was used to assay plasma levels of 14 polychlorinated biphenyl (PCB) congeners and 11 organochlorine (OC) pesticides among cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant trends of increased CMM risk were observed with increasing plasma concentrations of multiple PCB congeners, including PCBs 138, 153, 170, 180, 183 and 187. For example, compared to lowest plasma concentration quartile of PCB\u2010138, the second, third and fourth quartiles were associated with 1.7 (95% CI: 0.9\u20132.9), 2.3 (95% CI: 1.3\u20134.1) and 2.4 (95% CI: 1.3\u20134.5) \u2010fold increased risks of CMM, respectively. Similarly, increasing plasma concentrations of several OC pesticides (i.e., \u03b2\u2010HCH, HCB, Mirex, oxychlordane and trans\u2010Nonachlor) showed statistically significant trends with increased CMM risk. For example, compared to lowest plasma concentration quartile of \u03b2\u2010HCH, the second, third and fourth quartiles were associated with 1.3 (95% CI: 0.7\u20132.3), 2.1 (95% CI: 1.2\u20133.7) and 2.3 (95% CI: 1.2\u20134.4) \u2010fold increased risks of CMM, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Plasma levels of several persistent organic pollutants were highly correlated, suggesting that observed associations were not necessarily independent of each other. Given the highly correlated nature of exposure to PCB and OC analytes, sophisticated analyses that consider complex mixtures should be considered in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1536","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T07:10:33Z","timestamp":1629443433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Persistent organic pollutants and risk of cutaneous malignant melanoma among women"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-0564","authenticated-orcid":false,"given":"Maryam","family":"Darvishian","sequence":"first","affiliation":[{"name":"Cancer Control Research Program BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Cancer Control Research Program BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Gaudreau","sequence":"additional","affiliation":[{"name":"Centre de Toxicologie du Qu\u00e9bec (CTQ) Institut National de Sant\u00e9 Publique du Qu\u00e9bec (INSPQ)  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenaida","family":"Abanto","sequence":"additional","affiliation":[{"name":"Cancer Control Research Program BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Choi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Cancer Control Research Program BC Cancer  Vancouver British Columbia Canada"},{"name":"Department of Dermatology and Skin Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Spinelli","sequence":"additional","affiliation":[{"name":"School of Population and Public Health University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Cancer Control Research Program BC Cancer  Vancouver British Columbia Canada"},{"name":"Department of Dermatology and Skin Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Canadian cancer statistics 2019","author":"Canadian Cancer Statistics Advisory Committee","year":"2019"},{"key":"e_1_2_10_3_1","first-page":"190","article-title":"Cancer incidence in British Columbia expected to grow by 57% from 2012 to 2030","volume":"57","author":"Woods RR","year":"2015","journal-title":"B C Med J"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.10.016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25503"},{"key":"e_1_2_10_6_1","unstructured":"IARC. 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