{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:43:40Z","timestamp":1753868620900,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although cervical cancer is one of the most common malignancies in pregnancy, its management mainly follows the guidelines for nonpregnant disease state. Within the limited time, patients, and healthcare workers must make difficult decisions to either delay treatment until documented fetal maturity or start immediate treatment based on the disease stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>The patient was a 37\u2010year\u2010old woman: gravida 1, para 0. Her cervical cytology revealed a high\u2010grade squamous intraepithelial lesion at 8\u2009weeks' gestation. Moreover, invasive squamous cell carcinoma was suspected based on the findings of uterine cervix biopsy. Cervical conization was performed at 11\u2009weeks' gestation, confirming a histopathological diagnosis of squamous cell carcinoma, pT1b2. Cervical cytology findings continued to be negative for intraepithelial lesion or malignancy from 2\u2009weeks after conization until 2\u2009weeks before a cesarean section. In addition, we performed abdominal pelvic lymphadenectomy at 16\u2009weeks' gestation to determine whether the patient could continue her pregnancy. No lymph node metastasis or local recurrence was observed. Finally, a cesarean section and modified radical hysterectomy were performed at 35\u2009weeks' gestation. There was no carcinoma invasion or metastasis. A baby girl weighing 2056\u2009g was delivered with 1\u2010 and 5\u2010min Apgar scores of 8 and 9, respectively. Five years postoperatively, there was no evidence of cancer recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Management of cervical cancer during pregnancy by using a combination strategy of deep conization and pelvic lymphadenectomy could be an effective strategy for carefully and safely assessing risks of recurrence and metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1542","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T06:15:25Z","timestamp":1631772925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful pregnancy with stage <scp>IB2<\/scp> uterine cervical cancer: A case report"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3636-141X","authenticated-orcid":false,"given":"Saya","family":"Nagasawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Nerima Hospital  Nerima\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Nerima Hospital  Nerima\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Juntendo University Nerima Hospital  Nerima\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soshi","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Nerima Hospital  Nerima\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayoi","family":"Sugimori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Nerima Hospital  Nerima\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Nerima Hospital  Nerima\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Juntendo University Nerima Hospital  Nerima\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-7613","authenticated-orcid":false,"given":"Daiki","family":"Ogishima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Nerima Hospital  Nerima\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1067\/S0002-9378(03)00537-4"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"207","article-title":"Outcome of pregnancies after cold\u2010knife conization of the uterine cervix during pregnancy","volume":"23","author":"Demeter A","year":"2002","journal-title":"Eur J Gynaecol Oncol"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1111\/j.1749-6632.2001.tb03809.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1016\/j.bpobgyn.2005.03.002"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1097\/00006254-200010000-00022"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1200\/JCO.1991.9.11.1956"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1093\/annonc\/mdi084"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"79","article-title":"ACOG practice bulletin. Diagnosis and treatment of cervical cancer. Number 35, May 2002. American College of Obstetricians and Gynecologists","volume":"78","author":"American College of Obstetricians and Gynecologists","year":"2002","journal-title":"Int J Gynaecol Obstet"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1097\/01.AOG.0000216015.15415.5f"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1111\/j.1525-1438.2008.01193.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1016\/j.ajog.2009.05.002"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1016\/j.ygyno.2009.10.042"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1016\/j.ejogrb.2010.05.018"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1016\/j.ygyno.2010.12.357"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1007\/s10147-011-0209-3"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1016\/j.ejogrb.2011.04.048"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1097\/IGC.0b013e31824ff142"},{"key":"e_1_2_10_19_1","first-page":"926502","article-title":"Radical abdominal trachelectomy for ib1 cervical cancer at 17\u2009weeks of gestation: a case report and literature review","volume":"2014","author":"Aoki Y","year":"2014","journal-title":"Case Rep Obstet Gynecol"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.1097\/IGC.0000000000001218"},{"issue":"5","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2009.07.1000","article-title":"The therapeutic management of a twin pregnancy complicated by the presence of cervical cancer, following laparoscopic staging and chemotherapy, with an emphasis on cisplatin concentrations in the fetomaternal compartments amnion fluid, umbilical cord, and maternal serum","volume":"92","author":"Marnitz S","year":"2009","journal-title":"Fertil Steril"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1093\/humupd\/7.4.384"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_1","DOI":"10.1016\/j.ejogrb.2013.09.008"},{"doi-asserted-by":"publisher","key":"e_1_2_10_24_1","DOI":"10.1016\/0090-8258(90)90072-S"},{"doi-asserted-by":"publisher","key":"e_1_2_10_25_1","DOI":"10.1177\/1758834013494988"},{"doi-asserted-by":"publisher","key":"e_1_2_10_26_1","DOI":"10.1016\/S0140-6736(11)60829-5"},{"doi-asserted-by":"publisher","key":"e_1_2_10_27_1","DOI":"10.1097\/GRF.0b013e31825c8be5"},{"doi-asserted-by":"publisher","key":"e_1_2_10_28_1","DOI":"10.1097\/IGC.0000000000000062"},{"doi-asserted-by":"publisher","key":"e_1_2_10_29_1","DOI":"10.1016\/j.ygyno.2007.12.006"},{"doi-asserted-by":"publisher","key":"e_1_2_10_30_1","DOI":"10.1006\/gyno.1995.1091"},{"doi-asserted-by":"publisher","key":"e_1_2_10_31_1","DOI":"10.1006\/gyno.1999.5420"},{"doi-asserted-by":"publisher","key":"e_1_2_10_32_1","DOI":"10.1093\/annonc\/mdz228"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1542","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T06:50:36Z","timestamp":1692859836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/cnr2.1542"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1542","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"2021-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1542"}}