{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T23:05:43Z","timestamp":1762643143090,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20kk0305014","JP20ck0106467"],"award-info":[{"award-number":["20kk0305014","JP20ck0106467"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K22608"],"award-info":[{"award-number":["19K22608"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An atypical form of Burkitt leukemia\/lymphoma (BL), BL with a phenotype of precursor B\u2010cells (preBLL), is listed in the WHO Classification. Recent reports suggested that preBLL and classical BL could be distinguished by the differences in IG\u2010<jats:italic>MYC<\/jats:italic> translocation architecture and an additional mutated genes profile. The characteristics of classical BL are IG\u2010<jats:italic>MYC<\/jats:italic> by aberrant somatic hypermutation or class switch recombination, and BL\u2010specific gene mutations such as <jats:italic>MYC<\/jats:italic>, <jats:italic>ID3<\/jats:italic>, and <jats:italic>CCND3<\/jats:italic>. Meanwhile, preBLL is characterized by IG\u2010<jats:italic>MYC<\/jats:italic> due to aberrant VDJ recombination and mutations in <jats:italic>NRAS<\/jats:italic> and <jats:italic>KRAS<\/jats:italic>. However, it is not clear whether all preBLL cases can be differentiated. This report investigated the molecular characteristics of an infant preBLL case, with a more advanced stage of maturity than typical preBLL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>The patient showed BL\u2010like morphology with IGH\u2010<jats:italic>MYC<\/jats:italic> rearrangement. In the immunophenotyping, CD20 and surface immunoglobulin were negative, whereas other markers were consistent with BL. To evaluate the genetic contribution, we performed whole\u2010exome sequencing. The breakpoint analysis revealed the IG\u2010<jats:italic>MYC<\/jats:italic> occurred due to an aberrant VDJ recombination. Meanwhile, additional somatic mutations were detected in <jats:italic>FBXO11<\/jats:italic>, one of the mutant genes specific to BL. In the analysis of the specimen in complete remission, mutation in <jats:italic>KRAS<\/jats:italic>, frequently mutated in preBLL, was detected with low frequency, suggesting somatic mosaicism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present case showed the characteristics of both typical preBLL and classical BL. Because preBLL includes atypical cases such as the present case, further studies are required to elucidate preBLL features.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1545","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T12:12:14Z","timestamp":1630584734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic features of precursor B\u2010cell phenotype Burkitt leukemia with <scp>IGH\u2010<\/scp><i>MYC<\/i> rearrangement"],"prefix":"10.1002","volume":"5","author":[{"given":"Masanori","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Center for Child Health and Development  Tokyo Japan"},{"name":"Department of Pediatrics Yokohama City University  Yokohama 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