{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:09:24Z","timestamp":1787738964695,"version":"build-2784847793"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contemporary data of peripheral T\u2010cell lymphoma (PTCL) and natural\u2010killer\/T\u2010cell lymphoma (NKTL) patients treated with ifosfamide, carboplatin and etoposide (ICE) are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We performed a retrospective analysis to estimate outcomes of ICE\u2010treated PTCL and NKTL patients at three tertiary cancer centres in Singapore.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Patients were identified through lymphoma databases from National Cancer Centre Singapore (NCCS), National University Hospital, Singapore (NUHS), and Singapore General Hospital (SGH). Responses and survival outcomes were determined from electronic medical records. A total of 75 patients with a median age of 50 were included. ICE was used as first\u2010line treatment in 14 patients (19%) and as subsequent lines of treatment in 61 patients (81%). The overall response rates (ORR) for all patients was 63% (40% complete response [CR]). The ORR and CR in the first line were 86% and 64% respectively. At a median follow\u2010up duration of 71.0\u00a0months, the median progression\u2010free (PFS) and overall survival (OS) for all patients were 4.4\u00a0months (95%CI, 2.7\u20136.0) and 16\u2009months (95%CI, 8.3\u201345.4) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, ICE showed high ORR but poor PFS in relapsed\/refractory PTCL and NKTL. ORR of ICE in the first line setting appears better than real\u2010world CHOP data and warrants further study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1552","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T10:11:53Z","timestamp":1651140713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment outcomes of T and natural\u2010killer\/T\u2010cell lymphoma with ifosfamide, carboplatin and etoposide chemotherapy"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-2608","authenticated-orcid":false,"given":"Tricia","family":"Tay","sequence":"first","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6580-0920","authenticated-orcid":false,"given":"Nagavalli","family":"Somasundaram","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials &amp; Epidemiological Sciences National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lay Poh","family":"Khoo","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan Zhi Kai","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh Shan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Hospital Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Tao","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Quek","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Farid","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Poon","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Y. S.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther W. Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie S. W.","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeow Tee","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Diong","sequence":"additional","affiliation":[{"name":"Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas F.","family":"Grigoropoulos","sequence":"additional","affiliation":[{"name":"Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-2226","authenticated-orcid":false,"given":"Chandramouli","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Hospital Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"de Mel","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Hospital Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Jeyasekharan","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Hospital Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther H. L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Hospital Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Hospital Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen Lin","family":"Chee","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Hospital Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Thye","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"76","article-title":"Prognostic significance of T\u2010cell phenotype in aggressive non\u2010Hodgkin's lymphomas. Groupe d'Etudes des Lymphomes de l'Adulte (GELA)","volume":"92","author":"Gisselbrecht C","year":"1998","journal-title":"Blood"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.12.4514"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6287"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-431460"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg702"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.41"},{"key":"e_1_2_9_9_1","first-page":"555","article-title":"Nuclear expression of MATK is a novel marker of type II enteropathy\u2010associated T\u2010cell lymphoma","volume":"25","author":"Tan SY","year":"2011","journal-title":"Nat Publ Group"},{"key":"e_1_2_9_10_1","first-page":"416","article-title":"A phase I study of romidepsin and ifosfamide, carboplatin, etoposide for the treatment of patients with relapsed or refractory peripheral T\u2010cell lymphoma","volume":"103","author":"Strati P","year":"2018","journal-title":"Haematol Ferr Stor Foun"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32984-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00768.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-573089"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1552","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T12:19:21Z","timestamp":1692793161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,28]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/cnr2.1552"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1552","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,28]]},"assertion":[{"value":"2021-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1552"}}