{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:50:25Z","timestamp":1758815425677,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary neuroendocrine carcinomas (NECs) are very rare entities accounting for 0.49% of all malignancies. Within the head and neck, the most common sites are the larynx and paranasal sinuses, while the hypopharynx is seldom described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We present a patient with a poorly differentiated metastatic NEC of the hypopharynx treated palliatively with organ\u2010preserving surgery and post\u2010operative chemotherapy, and literature review for well\u2010documented pure hypopharyngeal NECs. Our patient died of chest infection during chemotherapy, 4\u2009months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chemotherapy remains the mainstay of treatment in the presence of metastases with 2\u2010year overall survival of 15.7%. Due to the aggressive nature of poorly differentiated metastatic NECs, surgical management is seldom considered. We report and advocate the successful palliative role of organ\u2010preserving, minimally invasive trans\u2010oral LASER micro\u2010surgery and neck dissection to control loco\u2010regional head and neck disease, safe\u2010guarding better quality of home life, despite limited life expectancy for this condition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1558","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T16:02:32Z","timestamp":1633622552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgical palliation in poorly differentiated neuroendocrine carcinoma of the hypopharynx: Case report"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-8070","authenticated-orcid":false,"given":"Francesca Romana","family":"Fiorini","sequence":"first","affiliation":[{"name":"Departmentof Otolaryngology and Head and Neck Northwick Park Hospital  London 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