{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:43:41Z","timestamp":1753868621914,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent shifts from radiation to chemotherapy\u2010based treatment for acute lymphoblastic leukemia (ALL) have contributed to reduced long\u2010term morbidity. Despite this, ALL survivors remain at increased risk for long\u2010term cognitive impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify demographic and treatment factors associated with school performance in pediatric survivors of ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected standardized test scores for reading, math, and science obtained in a school setting from grades 3\u201311 in 63 ALL survivors (46.0% boys). Most participants were assessed across multiple grades (median number of grades <jats:italic>n<\/jats:italic>\u00a0=\u00a05, range 1\u20137), and 269 observations were considered in the analyses. Treatment exposures were extracted from medical records. Socio\u2010economic status was estimated using participation in free\/reduced lunch programs at school. Mixed effects linear regression models were conducted to determine factors associated with school performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ALL survivors' scores were comparable to state norms on reading, math, and science performances. On multivariable analysis, participation in free\/reduced lunch programs was significantly associated with lower reading scores (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u221212.52; 95% CI \u221222.26:\u22122.77, <jats:italic>p\u2009=<\/jats:italic>\u00a0.01). Exposure to radiation during treatment was also associated with lower reading test scores (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u221230.81, 95% CI \u221252.00:\u22129.62, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). No significant associations between demographics and treatment parameters were observed for math and science test scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We utilized population\u2010based achievement tests conducted from grades 3\u201311 to characterize school performance in ALL survivors. Our results imply that survivors with low socio\u2010economic status and those exposed to radiation during treatment could benefit from early monitoring and intervention to maximize academic success.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1560","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T08:02:08Z","timestamp":1633075328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing academic performance in pediatric acute lymphoblastic leukemia with population\u2010based achievement tests"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-5521","authenticated-orcid":false,"given":"Hend M.","family":"Al\u2010Kaylani","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Iowa Hospital and Clinics  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin 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