{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:56:58Z","timestamp":1787317018943,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Invasive mammary Paget's disease (MPD) is an extremely rare eczematous eruption on the nipple and areola with an invasion of the dermis by Paget cells. This entity can often be misdiagnosed and overtreated for invasive carcinoma of the breast.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A 34\u2010year woman presented with a 2\u2010year history of right nipple eczema and right axillary lump for a month. Breast ultrasound revealed dilated intra\u2010nipple lactiferous duct and an enlarged right axillary lymph node. Histopathology from biopsy revealed MPD with ductal carcinoma in situ (DCIS) whereas final histopathology after right modified radical mastectomy revealed Invasive MPD with DCIS and axillary metastasis. She underwent adjuvant chemotherapy and is under hormonal therapy with complete remission for 18\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Awareness of invasive MPD is important to avoid misdiagnosis and probable radical treatment. Close follow\u2010up is warranted due to limited knowledge regarding treatment and prognosis of invasive MPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.1572","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T23:25:44Z","timestamp":1635377144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Paget's disease of nipple with dermal invasion: A case report"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-8907","authenticated-orcid":false,"given":"Rubina","family":"Maharjan","sequence":"first","affiliation":[{"name":"Department of Oncology Nepal Cancer Hospital and Research Center  Harisiddhi, Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6888-260X","authenticated-orcid":false,"given":"Suraj","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus Institute of Medicine  Maharajgunj, Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prafulla","family":"Shakya","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology (Breast Unit) Nepal Cancer Hospital and Research Center  Harisiddhi, Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9591-3168","authenticated-orcid":false,"given":"Sanjeev","family":"Kharel","sequence":"additional","affiliation":[{"name":"Maharajgunj Medical Campus Institute of Medicine  Maharajgunj, Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aagon Krishna","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology (Breast Unit) Nepal Cancer Hospital and Research Center  Harisiddhi, Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moushami","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology Nepal Cancer Hospital and Research Center  Harisiddhi, Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950101)75"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22137"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.08.015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896914525229"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1446-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqz113.016"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318259ef7f"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197009)26:3\u2329680::aid-cncr2820260329\u232a3.0.co;2-p"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-015-0415-z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-6-10"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/LM00DUW2SRHOSUWD"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.147870"},{"key":"e_1_2_11_14_1","first-page":"1510","article-title":"Mammary Paget's disease: a rare case of early dermal invasion","volume":"3","author":"Deane R","year":"2018","journal-title":"Clin Oncol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5741"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0611-OA"}],"container-title":["Cancer 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