{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:41:16Z","timestamp":1790185276621,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Philadelphia\u2010like (Ph\u2010like) acute lymphoblastic leukemia (ALL) is a subtype of pediatric leukemia with high risk factors and poor outcome. There are few reports of its prevalence in Latin America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated the frequency and clinical and biological characteristics of Ph\u2010like ALL in a pediatric cancer center in Colombia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Ph\u2010like genetic profile was analyzed by a low\u2010density array (LDA). Samples from patients with Ph\u2010like ALL were analyzed by fluorescent in situ hybridization for cytokine receptor like factor 2 (<jats:italic>CRLF2)<\/jats:italic> and ABL proto\u2010oncogene 1, non\u2010receptor tyrosine kinase (<jats:italic>ABL1)<\/jats:italic> rearrangements. Copy number variations were assessed by multiplex ligation probe amplification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 121 patients were analyzed. Fifteen patients (12.4%) had Ph\u2010like ALL, and these patients had significantly higher leukocyte counts at diagnosis and higher levels of minimal residual disease on days 15 and 33 of induction than patients without the Ph\u2010like subtype. There were no significant differences in sex, age, or response to prednisone at day 8 between the two groups. <jats:italic>CRLF2<\/jats:italic> rearrangements were identified in eight patients, and <jats:italic>ABL1<\/jats:italic> rearrangements were identified in two patients. Other genetic alterations alone or in combination were identified in 77% of patients, including deletions in cyclin dependent kinase inhibitor 2 A\/B (46.2%), IKAROS family zinc finger 1 (38.3%), and paired box 5 (30.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ph\u2010like ALL had a 12.4% prevalence in our cohort of patients with pediatric ALL. The identification of this group of patients has importance for risk stratification and future targeted therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1587","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T11:07:05Z","timestamp":1637147225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Philadelphia\u2010like acute lymphoblastic leukemia: Characterization in a pediatric cohort in a referral center in Colombia"],"prefix":"10.1002","volume":"5","author":[{"given":"Adriana","family":"Linares Ballesteros","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology Unit HOMI Fundaci\u00f3n Hospital Pedi\u00e1trico la Misericordia  Bogot\u00e1 Colombia"},{"name":"Grupo Oncohematolog\u00eda Pedi\u00e1trica Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Karime","family":"Yunis","sequence":"additional","affiliation":[{"name":"Servicios M\u00e9dicos Yunis Turbay y C\u00eda S.A.S. Instituto de Gen\u00e9tica  Bogot\u00e1 Colombia"},{"name":"Grupo de Patolog\u00eda Molecular Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Unit HOMI Fundaci\u00f3n Hospital Pedi\u00e1trico la Misericordia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Aponte","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Unit HOMI Fundaci\u00f3n Hospital Pedi\u00e1trico la Misericordia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Flechas","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Unit HOMI Fundaci\u00f3n Hospital Pedi\u00e1trico la Misericordia  Bogot\u00e1 Colombia"},{"name":"Grupo Oncohematolog\u00eda Pedi\u00e1trica Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1756-6812","authenticated-orcid":false,"given":"Cindy","family":"Martinez","sequence":"additional","affiliation":[{"name":"Grupo Oncohematolog\u00eda Pedi\u00e1trica Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Uribe","sequence":"additional","affiliation":[{"name":"Pediatric Pathology Unit HOMI Fundaci\u00f3n Hospital Pediatrico la Misericordia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Quintero","sequence":"additional","affiliation":[{"name":"Pediatric Pathology Unit HOMI Fundaci\u00f3n Hospital Pediatrico la Misericordia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Servicios M\u00e9dicos Yunis Turbay y C\u00eda S.A.S. Instituto de Gen\u00e9tica  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Pardo","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Unit HOMI Fundaci\u00f3n Hospital Pedi\u00e1trico la Misericordia  Bogot\u00e1 Colombia"},{"name":"Grupo Oncohematolog\u00eda Pedi\u00e1trica Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Cristina","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"Grupo Oncohematolog\u00eda Pedi\u00e1trica Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Contreras","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Unit HOMI Fundaci\u00f3n Hospital Pedi\u00e1trico la Misericordia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jose","family":"Yunis","sequence":"additional","affiliation":[{"name":"Servicios M\u00e9dicos Yunis Turbay y C\u00eda S.A.S. Instituto de Gen\u00e9tica  Bogot\u00e1 Colombia"},{"name":"Grupo de Patolog\u00eda Molecular Universidad Nacional de Colombia  Bogot\u00e1 Colombia"},{"name":"Departamento de Patolog\u00eda, Facultad de Medicina e Instituto de Gen\u00e9tica Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.4946"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0642-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808253"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70339-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12050687"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403088"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.247973"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245944"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.207019"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-119541"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.120"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119061199"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-12-758979"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.03.299"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2018.05.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2021.101242"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-743252"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.4105"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.0073"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.08.011"},{"issue":"1","key":"e_1_2_9_23_1","article-title":"Characterization of CRLF2 expression in pediatric B\u2010cell precursor acute lymphoblastic leukemia","volume":"67","author":"Rasekh EO","year":"2021","journal-title":"Clin Lab"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-462358"},{"issue":"1","key":"e_1_2_9_25_1","first-page":"1322","article-title":"Ruxolitinib or dasatinib in combination with chemotherapy for patients with relapsed\/refractory Philadelphia (Ph)\u2010like acute lymphoblastic leukemia: a phase I\u2010II trial","volume":"130","author":"Jain N","year":"2017","journal-title":"Blood"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000053"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-110221"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:22:12Z","timestamp":1692948132000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,17]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/cnr2.1587"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1587","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,17]]},"assertion":[{"value":"2021-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1587"}}