{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:02:09Z","timestamp":1780113729097,"version":"3.54.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intracranial germinomas (GN) are rare cancers that primarily affect children, making them rarer still in adults. Standard treatment for this neoplasm includes neoadjuvant chemotherapy (NC) followed by radiotherapy (RT) or RT at a higher dose and larger field. These recommendations are based on studies focused mostly on children; it is currently unclear whether this treatment is applicable to adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We present a case of a 23\u2010year\u2010old adult male with no underlying pathologies, drug allergies, or family history of cancer, who presented for medical evaluation with blurred vision, diplopia, forgetfulness, and weight loss starting 3\u20134\u00a0months before the evaluation. Clinical examination indicated Parinaud's Syndrome. Magnetic resonance imaging (MRI) and computed tomography (CT) revealed a pineal tumor with ependymal dissemination in both lateral ventricles, which was causing obstructive hydrocephalus. The patient had surgery consisting of ventriculostomy, Holter shunt insertion, cisternal ventricular intubation, and cisterna magna anastomosis to improve ventricular drainage. Pathology confirmed pineal germinoma. Cerebrospinal fluid cytology and MRI of the axis were negative. Four cycles of NC were given to the patient (carboplatin, etoposide, and ifosfamide), with reduced dosage. Once a partial volumetric response was confirmed, whole\u2010ventricular radiotherapy (WVR) was initiated with a total tumor bed dose of 45\u2009Gy over 25 sessions in 5\u2009weeks. Optimum clinical results were observed, and no short\u2010term (&lt;90\u2009day) radiation toxicity was observed. The patient was able to resume his normal activities soon after treatment. Follow\u2010ups over 2\u2009years post\u2010surgery indicated continued control of the lesion and absence of symptoms except for mild diplopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although this is a case report, these data suggest that a reduced NC course and WVR may effectively treat adult GN. This protocol likely decreases the risk of undesirable NC and RT secondary effects, while providing excellent local control; however, using a narrower RT field is not recommended.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1611","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T06:34:33Z","timestamp":1648535673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pineal germinoma in a young adult: A case report"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4357-4261","authenticated-orcid":false,"given":"Lissett Jeanette","family":"Fern\u00e1ndez\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"School of Medicine Universidad Privada Antenor Orrego  Trujillo La Libertad Peru"},{"name":"Department of Medicine Hospital de Alta Complejidad Virgen de la Puerta  La Esperanza La Libertad 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