{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:43:46Z","timestamp":1753868626489,"version":"3.41.2"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["UVA2012\u20105517","UVA2015\u20107655"],"award-info":[{"award-number":["UVA2012\u20105517","UVA2015\u20107655"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse late health outcomes after multimodal treatment for pediatric cancer are diverse and of prime interest. Currently available evidence and survivorship care guidelines are largely based on studies addressing side\u2010effects of two dimensional planned radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The Dutch pediatric 3D\u2010planned radiotherapy (3D\u2010RT) study aims to gain insight in the long\u2010term health outcomes among children who had radiotherapy in the 3D era. Here, we describe the study design, data\u2010collection methods, and baseline cohort characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The 3D\u2010RT study represents an expansion of the Dutch Childhood Cancer Survivor study (DCCSS) LATER cohort, including pediatric cancer patients diagnosed during 2000\u20132012, who survived at least 5\u2009years after initial diagnosis and 2\u2009years post external beam radiotherapy. Individual cancer treatment parameters were obtained from medical files. A national infrastructure for uniform collection and archival of digital radiotherapy files (Computed Tomography [CT]\u2010scans, delineations, plan, and dose files) was established. Health outcome information, including subsequent tumors, originated from medical records at the LATER outpatient clinics, and national registry\u2010linkage. With a median follow\u2010up of 10.9 (interquartile range [IQR]: 7.9\u201314.3) years after childhood cancer diagnosis, 711 eligible survivors were identified. The most common cancer types were Hodgkin lymphoma, medulloblastoma, and nephroblastoma. Most survivors received radiotherapy directed to the head\/cranium only, the craniospinal axis, or the abdominopelvic region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 3D\u2010RT study will provide knowledge on the risk of adverse late health outcomes and radiation\u2010associated dose\u2010effect relationships. This information is valuable to guide follow\u2010up care of childhood cancer survivors and to refine future treatment protocols.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1620","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T13:51:52Z","timestamp":1675086712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adverse late health outcomes among children treated with <scp>3D<\/scp> radiotherapy techniques: Study design of the <scp>Dutch<\/scp> pediatric <scp>3D\u2010RT<\/scp> study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1455-9545","authenticated-orcid":false,"given":"Josien G. M.","family":"Beijer","sequence":"first","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-7195","authenticated-orcid":false,"given":"Judith L.","family":"Kok","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert O.","family":"Janssens","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Radiation Oncology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Streefkerk","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrica C. H.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Pediatric Oncology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleo","family":"Slagter","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Maduro","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Radiation Oncology, University of Groningen University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra S.","family":"Kroon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha A.","family":"Grootenhuis","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eline","family":"van Dulmen\u2010den Broeder","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology Amsterdam University Medical Center\/Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline J.","family":"Loonen","sequence":"additional","affiliation":[{"name":"Department of Hematology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Wendling","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim J. E.","family":"Tissing","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Beatrix Children's Hospital University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena J.","family":"van der Pal","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marloes","family":"Louwerens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjan","family":"Bel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Amsterdam University Medical Center\/University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap","family":"den Hartogh","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Dutch Childhood Cancer Parent Organization  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margriet","family":"van der Heiden\u2010van der Loo","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leontien C. M.","family":"Kremer","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Pediatrics, Emma Children's Hospital Amsterdam University Medical Center\/University of Amsterdam  Amsterdam The Netherlands"},{"name":"University Medical Center Utrecht, Wilhelmina Children's Hospital  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-2677","authenticated-orcid":false,"given":"Jop C.","family":"Teepen","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-4657","authenticated-orcid":false,"given":"C\u00e9cile M.","family":"Ronckers","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.11.042"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.11.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.11.022"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.3114"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331835"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-018-0297-x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.24.2705"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1687::AID-CNCR24>3.0.CO;2-M"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1316"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1008648"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.6902"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2016.09.013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00562"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70409-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.058"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30688-4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2018.12.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/028418600750013249"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0997"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HP.0000326342.47348.06"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25285"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000002445"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","unstructured":"TeepenJC KokJL FeijenEAM et al.Questionnaire\u2010 and linkage\u2010based outcomes in Dutch childhood cancer survivors: methodology of the DCCSS LATER study part 1. 2021.","DOI":"10.1002\/cam4.5519"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy124"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20910"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/489\/1\/012099"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2009.04.008"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-020-00880-0"},{"volume-title":"Common Terminology Criteria for Adverse Events (CTCAE), Version 4.0","year":"2009","author":"U.S. Department of Health and Human Services","key":"e_1_2_10_30_1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328320acea"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.04.031"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh870"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14178"},{"issue":"1","key":"e_1_2_10_35_1","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"Casparie M","year":"2007","journal-title":"Cell Oncol"},{"volume-title":"Cancer Incidence in Five Continents","year":"2014","author":"Forman D","key":"e_1_2_10_36_1"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-3-10"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23715"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.03.021"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2021.04.007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-1-10"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.02.019"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.03.033"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.05.016"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR15201.1"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/2\/002"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(98)00099-1"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.074"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-11-3"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-020-02522-5"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009122"},{"issue":"38","key":"e_1_2_10_52_1","first-page":"1445","article-title":"Acute lymphatic leukemia in children in The Netherlands; study ALL I, 1972\u20101973; Dutch childhood leukemia study group","volume":"119","author":"Berg A","year":"1975","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.258"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.10.040"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.11.073"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.02.001"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.04.023"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1620","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T08:08:14Z","timestamp":1692432494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/cnr2.1620"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1620","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"assertion":[{"value":"2021-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1620"}}