{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:43:49Z","timestamp":1753868629895,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Case<\/jats:title><jats:p>We herein present a case of the co\u2010occurrence of <jats:italic>JAK2<\/jats:italic>\u2010mutated essential thrombocythemia (ET) with chronic lymphocytic leukemia (CLL) harboring the recurrent and rare whole\u2010arm translocation, der(8;17)(q10;q10). The co\u2010existence of lymphoproliferative neoplasms and myeloproliferative neoplasms is suggested to be a rare event. Under this condition, the lymphoproliferative disorder presents a clinically indolent course with a low\u2010risk biological profile. However, the present case showed aggressive disease progression, reflecting a poor prognostic factor; that is, the loss of 17p caused by the whole\u2010arm der(8;17)(q10;q10) translocation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present case report emphasizes the importance of considering the involvement of a genetically poor prognostic factor, regardless of the co\u2010occurrence of CLL and ET.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1658","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T06:04:48Z","timestamp":1655532288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Co\u2010occurrence of <scp><i>JAK2<\/i> V617F<\/scp>\u2010mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10)"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9065-2437","authenticated-orcid":false,"given":"Masahiro","family":"Manabe","sequence":"first","affiliation":[{"name":"Department of Hematology Osaka General Hospital of West Japan Railway Company  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Tanizawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka General Hospital of West Japan Railway Company  Osaka Japan"},{"name":"Hematology, Graduate School of Medicine Osaka City University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Nanno","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka General Hospital of West Japan Railway Company  Osaka 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