{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:06:30Z","timestamp":1773842790552,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous angiosarcoma (AS) of the head and neck is a rare highly aggressive tumor, often associated with difficult local control of the disease and poor prognosis. This article describes a case of multifocal cutaneous AS of the scalp, mainly addressing its difficult surgical management and challenging reconstruction and concludes with a review of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 70\u2010year\u2010old Caucasian male was referred to our hospital with a growing scalp lesion initially suspected to be benign, but later diagnosed with AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient had tumor recurrence and a difficult reconstruction for which dermal substitutes proved very useful.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AS can mimic a benign lesion in its early stages. Skin substitutes, namely dermal templates, can be useful to meet the complex needs of reconstruction and oncological surveillance of patients with AS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1659","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T11:39:55Z","timestamp":1657625995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multifocal cutaneous angiosarcoma of the scalp\u2014A challenging reconstructive case managed with skin substitutes"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8349-8857","authenticated-orcid":false,"given":"Henrique","family":"Messias","sequence":"first","affiliation":[{"name":"Head and Neck Surgery Department Portuguese Institute of Oncology Francisco Gentil  Lisbon Portugal"},{"name":"Division of Health Sciences University of Edinburgh  Edinburgh United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariluz","family":"Martins","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department Portuguese Institute of Oncology Francisco Gentil  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Zagalo","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department Portuguese Institute of Oncology Francisco Gentil  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Gomes","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department Portuguese Institute of Oncology Francisco Gentil  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2015.03.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2017.01.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08408-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08411-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70023-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000227544.01779.52"},{"key":"e_1_2_10_8_1","first-page":"8409820","article-title":"Extensive cutaneous scalp Angiosarcoma","volume":"2018","author":"Bhatti Z","year":"2018","journal-title":"Case Rep Dermatol Med"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24554"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556139907800416"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001865"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-021-00858-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24747"},{"key":"e_1_2_10_14_1","first-page":"8","article-title":"Cutaneous angiosarcoma of the head and neck resembling rosacea: a case report","volume":"10","author":"Wong A","year":"2020","journal-title":"SAGE Open Med Case Rep"},{"issue":"11","key":"e_1_2_10_15_1","first-page":"2303","article-title":"Angiosarcoma: a review of diagnosis and current treatment","volume":"9","author":"Cao J","year":"2019","journal-title":"Am J Cancer Res"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.763"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25701"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2020.07.026"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2018.06.013"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2021.01.009"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.3584"},{"issue":"2","key":"e_1_2_10_23_1","first-page":"117","article-title":"Surgical strategies for cutaneous neoplasm of the scalp. State of art","volume":"86","author":"Vitagliano T","year":"2015","journal-title":"Ann Ital Chir"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2013.02.004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181d8418e"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2014.889"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001748"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1530443"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12658"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000112746.67050.68"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-016-0703-0"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2019.07.024"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002775"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318201271c"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2020.04.018"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255501"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215121000918"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1659","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T11:17:19Z","timestamp":1692616639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,12]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/cnr2.1659"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1659","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,12]]},"assertion":[{"value":"2022-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1659"}}