{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:43:49Z","timestamp":1753868629424,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic myeloid leukemia (CML) is a rare disease in children and treated with tyrosine kinase inhibitors (TKI) and with allogeneic hematopoietic stem cell transplantation (HSCT) still in many cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We describe an 8\u2010year\u2010old patient with CML treated with two different TKIs before proceeding to allogeneic HSCT. Despite successful engraftment, prompt rejection of the graft was followed by autologous reconstitution. TKI therapy was reintroduced post\u2010rejection in anticipation of relapse but shortly discontinued due to low white blood cell and neutrophil counts. The patient has remained disease\u2010free over 5\u2009years after graft rejection and without further therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case suggests that even a short antileukemic effect by an allogeneic transplant may succeed in eradicating CML.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1663","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T09:54:00Z","timestamp":1657187640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-0678","authenticated-orcid":false,"given":"Susanna","family":"Vuorenoja","sequence":"first","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research, Tays Cancer Centre Tampere University Hospital, Tampere University  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Vettenranta","sequence":"additional","affiliation":[{"name":"Pediatric Research Center, University of Helsinki Helsinki University Central Hospital, University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli","family":"Lohi","sequence":"additional","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research, Tays Cancer Centre Tampere University Hospital, Tampere University  Tampere 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