{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:43:51Z","timestamp":1753868631764,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In malignancy, eosinophils have been shown to play an important role in the tumour micro\u2010environment. Increasingly, development of eosinophilia with immune checkpoint inhibitor (ICI) use is thought to be predictive of prognosis and development of immune\u2010related adverse events. However, there are many other causes for developing eosinophilia which can contribute to the difficulties in diagnosis and management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>Here, we present a case of <jats:italic>Strongyloides<\/jats:italic> parasitic infection as an uncommon differential for eosinophilia in a patient with lung cancer receiving a PDL\u20101 ICI, durvalumab, in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case highlights the complexities exploring the multiple potential causes of eosinophilia and the subsequent management, to allow safe continuation of ICI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1682","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T06:14:01Z","timestamp":1658211241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Strongyloides<\/i>\u2014An uncommon cause of eosinophilia whilst on durvalumab"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9177-7442","authenticated-orcid":false,"given":"Gaik Tin","family":"Quah","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Calvary Mater Newcastle  Waratah Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Calvary Mater Newcastle  Waratah Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Calvary Mater Newcastle  Waratah Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Calvary Mater Newcastle  Waratah 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Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1682","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T11:17:06Z","timestamp":1692616626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/cnr2.1682"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1682","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2022,7,18]]},"assertion":[{"value":"2021-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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