{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:54:02Z","timestamp":1779000842217,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ewing sarcoma (ES), the second most common malignant bone tumor after osteosarcoma in the second decade, occurs in 0.9% of cases as the primary non\u2010sacral form.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 20\u2010years\u2010old male presented with acute paraparesis of bilateral lower limb and numbness following initial back pain for the last 6\u2009months. Magnetic resonance imaging (MRI) of the lumbar spine revealed a 4\u00a0cm enhancing soft tissue mass at the L4\/L5 vertebra extending into the spinal canal with compression of the thecal sac. The computed tomography (CT) of the chest, abdomen, and pelvis revealed aggressive lytic lesions in the L4 spinous process with soft tissue extension into the spinal canal with no other site of distant metastasis. He was treated with IV steroids (Injection dexamethasone 10\u00a0mg IV followed by 4\u00a0mg tablet dexamethasone q6h; subsequently tapered off). A core needle biopsy showed a small, round blue cell neoplasm, (suggestive of a primitive neuroectodermal) stained positive for CD99 and vimentin stain. The diagnosis of ES lumbar spine was made which was treated with surgical resection with an appropriate margin measuring 8\u00a0\u00d7\u20094.5\u00a0\u00d7\u20092.5\u00a0cm with decompression and L4\/5 laminectomies, which had a negative margin in the surgical pathology report. Concomitant local radiotherapy and chemotherapy [cycles of vincristine 2\u00a0mg\/m<jats:sup>2<\/jats:sup>, adriamycin\/doxorubicin 75\u2009mg\/m<jats:sup>2<\/jats:sup>, cyclophosphamide 1200\u2009mg\/m<jats:sup>2<\/jats:sup> (VDC) with mesna rescue alternating with cycles of ifosfamide 1800\u2009mg\/m<jats:sup>2<\/jats:sup> and etoposide 100\u2009mg\/m<jats:sup>2<\/jats:sup> (IE)] was started. The motor strength was regained gradually with preserved spine biomechanics and oncological control with no recurrence in 2\u2010year follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presentation of lumbar ES can vary from local pain and swelling to acute paraparesis. Timely diagnosis and treatment with multimodal therapy, namely, steroids for acute spinal cord compression and surgery with chemoradiotherapy for ES can improve spinal biomechanics and oncological control.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1725","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T05:40:07Z","timestamp":1664862007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case report on non\u2010metastatic Ewing sarcoma of the lumbar spine in a young patient"],"prefix":"10.1002","volume":"5","author":[{"given":"Shobha","family":"Mandal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Guthrie Robert Packer Hospital  Sayre Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srijana","family":"Baniya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3045-1980","authenticated-orcid":false,"given":"Dipesh Kumar","family":"Rohita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine BP Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2195-9152","authenticated-orcid":false,"given":"Gopal Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine BP Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Lowry","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Guthrie Robert Packer Hospital  Sayre Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"StatPearls","author":"Durer S","year":"2022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/165289"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.54861"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70541-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199602)178:2<116::AID-PATH494>3.0.CO;2-H"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.05.015"},{"key":"e_1_2_9_8_1","unstructured":"BleyerA O' LearyM BarrR RiesL.Cancer epidemiology in older adolescents and young adults 15\u201329\u2009years of age including SEER incidence and survival:1975\u20132000. 2006. 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