{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:36:44Z","timestamp":1770748604910,"version":"3.50.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>T\u2010lymphoblastic lymphoma (T\u2010LBL) is an aggressive malignancy of T\u2010lymphoid precursors, rarely co\u2010occurring with myeloid\/lymphoid neoplasms with eosinophilia (M\/LNs\u2010Eo), with consequent rearrangement of tyrosine kinase (TK)\u2010related genes. The FIP1L1\u2010PDGFRA fusion gene is the most frequent molecular abnormality seen in eosinophilia\u2010associated myeloproliferative disorders, but is also present in acute myeloid leukemia (AML), T\u2010lymphoblastic leukemia\/lymphoma (TLL), or both simultaneously. T\u2010LBL mainly affects children and young adults, involving lymph node, bone marrow, and thymus. It represents about 85% of all immature lymphoblastic lymphomas, whereas immature B\u2010cell lymphomas comprise approximately 15% of all cases of LBL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>In this case report, we present an example of T cell lymphoblastic lymphoma with coexistent eosinophelia, treated successfully with a tyrosine\u2010kinase inhibitor (TKI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FIP1L1\u2010PDGFRA\u2010positive T\u2010LBL and myeloproliferative disorders have excellent response to low\u2010dose treatment with (TKI) imatinib. Most patients achieve rapid and complete hematologic and molecular remission within weeks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1769","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T03:32:03Z","timestamp":1671075123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>FIP1L1\u2010PDGFRA<\/scp> fusion gene in T\u2010lymphoblastic lymphoma: A case report"],"prefix":"10.1002","volume":"6","author":[{"given":"Salhah","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Hematology Mubarak Al\u2010Kabeer Hospital  Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmine","family":"Al\u2010Qattan","sequence":"additional","affiliation":[{"name":"Department of Hematology Mubarak Al\u2010Kabeer Hospital  Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walaa","family":"Awny","sequence":"additional","affiliation":[{"name":"Department of Hematopathology Kuwait Cancer Control Center  Kuwait Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz","family":"Hamadah","sequence":"additional","affiliation":[{"name":"Department of Hematology Kuwait Cancer Control Center  Kuwait Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Pathology Kuwait Cancer Center  Kuwait Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5597-5839","authenticated-orcid":false,"given":"Salem","family":"AlShemmari","sequence":"additional","affiliation":[{"name":"Department of Hematology Kuwait Cancer Control Center  Kuwait Kuwait"},{"name":"Department of Medicine, Faculty of Medicine Kuwait University  Kuwait Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13123102"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001822"},{"key":"e_1_2_12_4_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404662"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404154"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2007.06628.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.12.1391"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20359"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025217"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPMF03LVSBLHPJ"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSCR.904972"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1769","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.1769","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T02:01:14Z","timestamp":1692324074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/cnr2.1769"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1769","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]},"assertion":[{"value":"2021-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1769"}}