{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:40:50Z","timestamp":1777729250268,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical trials evaluating immune checkpoint inhibition (ICI) in recurrent high\u2010grade gliomas (rHGG) report 7%\u201320% 6\u2010month progression\u2010free survival (PFS), while re\u2010irradiation demonstrates 28%\u201339% 6\u2010month PFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluate outcomes of patients treated with ICI and concurrent re\u2010irradiation utilizing stereotactic body radiotherapy\/fractionated stereotactic radiosurgery (SBRT) compared to ICI monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Patients \u226518\u2010years\u2010old with rHGG (WHO grade III and IV) receiving ICI\u2009+\u2009SBRT or ICI monotherapy between January 1, 2016 and January 1, 2019 were included. Adverse events, 6\u2010month PFS and overall survival (OS) were assessed. Log\u2010rank tests were used to evaluate PFS and OS. Histogram analyses of apparent diffusion coefficient maps and dynamic contrast\u2010enhanced magnetic resonance perfusion metrics were performed. Twenty\u2010one patients with rHGG (ICI\u2009+\u2009SBRT: 16; ICI: 5) were included. The ICI\u2009+\u2009SBRT and ICI groups received a mean 7.25 and 6.2 ICI cycles, respectively. There were five grade 1, one grade 2 and no grade 3\u20135 AEs in the ICI\u2009+\u2009SBRT group, and four grade 1 and no grade 2\u20135 AEs in the ICI group. Median PFS was 2.85 and 1\u00a0month for the ICI\u2009+\u2009SBRT and ICI groups; median OS was 7 and 6\u00a0months among ICI\u2009+\u2009SBRT and ICI groups, respectively. There were significant differences in pre and posttreatment tumor volume in the cohort (12.35 vs. 20.51; <jats:italic>p<\/jats:italic>\u00a0=\u2009.03), but not between treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this heavily pretreated cohort, ICI with re\u2010irradiation utilizing SBRT was well tolerated. Prospective studies are warranted to evaluate potential therapeutic benefits to re\u2010irradiation with ICI\u2009+\u2009SBRT in rHGG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1788","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T02:44:50Z","timestamp":1675824290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Concurrent immunotherapy and re\u2010irradiation utilizing stereotactic body radiotherapy for recurrent high\u2010grade gliomas"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3488-6981","authenticated-orcid":false,"given":"Sean S.","family":"Mahase","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"},{"name":"Department of Radiation Oncology Penn State Cancer Institute  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Roytman","sequence":"additional","affiliation":[{"name":"Department of Radiology NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Roth O'Brien","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Ivanidze","sequence":"additional","affiliation":[{"name":"Department of Radiology NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore H.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan C.","family":"Pannullo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Ramakrishna","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv S.","family":"Magge","sequence":"additional","affiliation":[{"name":"Department of Neurology NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Healthcare Policy &amp; Research, Division of Biostatistics and Epidemiology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard A.","family":"Fine","sequence":"additional","affiliation":[{"name":"Department of Neurology NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Chia\u2010Yi","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Radiology NewYork Presbyterian\u2013Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P. 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