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Data regarding response to ALK\u2010targeting agents based on fusion partner is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 30\u2010year\u2010old female sought emergency care after onset of abdominal and lower back pain in 2019. Computed tomography (CT) demonstrated a cystic, mesenteric mass within the pelvis measuring up to 8.9\u00a0cm. Complete laparoscopic excision of the mass from the mesentery of the right colon and terminal ileum was performed. Pathologic assessment revealed IMT with a fusion between sequestosome 1 and ALK (<jats:italic>SQSTM1::ALK<\/jats:italic>), described in only two other cases of IMT. Four months after surgery, CT revealed multi\u2010focal, unresectable disease recurrence. She was referred to the University of Washington\/Fred\u00a0Hutchinson\u00a0Cancer\u00a0Center and placed on therapy with alectinib, after which she experienced a partial response. Three years after IMT recurrence, disease remains under control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the third reported case of IMT associated with the novel SQSTM1::ALK fusion protein, and the second treated with alectinib. Treatment with the ALK inhibitor alectinib appears to be active in this setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1792","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T03:04:59Z","timestamp":1675911899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inflammatory myofibroblastic tumor of the mesentery with a <i>SQSTM1::ALK<\/i> fusion responding to alectinib"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4700-7395","authenticated-orcid":false,"given":"Cass G. 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