{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:05Z","timestamp":1753868645200,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K07693"],"award-info":[{"award-number":["21K07693"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Carbon\u2010ion radiotherapy (C\u2010ion RT) is effective for head and neck mucosal melanoma (HN\u2010MM), including radioresistant mucosal melanoma. Melanoma also responds effectively to immune checkpoint inhibitors (ICIs). Data on the efficacy and safety of ICIs for HN\u2010MM are insufficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To analyze the efficacy and safety of ICI salvage therapy in patients with HN\u2010MM recurrence after C\u2010ion RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This retrospective study analyzed the medical records of 52 patients with HN\u2010MM treated with C\u2010ion RT between 2012 and 2020. A dose of 57.6 or 64.0\u2009Gy (relative biological effectiveness) was provided in 16 fractions. The primary endpoint was 3\u2010year overall survival (OS) rate. The median follow\u2010up time was 26.8\u2009months for all patients. A total of 29 patients had local recurrence or distant metastasis, and 16 patients who received ICI therapy. The 3\u2010year OS rate in the ICI group (<jats:italic>n<\/jats:italic>\u2009=\u200916) and best supportive care group (<jats:italic>n<\/jats:italic>\u2009=\u200913) were 53.8% and 0.0%, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.837); the difference was not statistically significant. There were no deaths after 1\u2009year among patients who underwent ICI therapy. No adverse events associated with C\u2010ion RT were related to or exacerbated by ICI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICI salvage therapy is effective and safe for patients with HN\u2010MM recurrence after C\u2010ion RT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1825","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T16:48:39Z","timestamp":1682700519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of immune checkpoint inhibitor treatment for head and neck mucosal melanoma recurrence in patients treated with carbon\u2010ion radiotherapy"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-8764","authenticated-orcid":false,"given":"Atsushi","family":"Musha","sequence":"first","affiliation":[{"name":"Gunma University Heavy Ion Medical Center  Maebashi Japan"},{"name":"Department of Oral 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