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Although there are standardized chemotherapy protocols in place, protocol changes made after extensive clinical trials demonstrate significant improvement in the efficacy and tolerability of certain drugs. The pharmacokinetics, pharmacodynamics, and tolerance of anti\u2010cancer medications are all highly individualized. A driving force behind these differences lies within a person's genetic makeup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent findings<\/jats:title>\n                    <jats:p>Pharmacogenomics, the study of how an individual's genes impact the processing and action of a drug, can optimize drug responsiveness and reduce toxicities by creating a customized medication regimen. However, these differences are rarely considered in the initial determination of standardized chemotherapeutic protocols and treatment algorithms. Because pharmacoethnicity is influenced by both genetic and nongenetic variables, clinical data highlighting disparities in the frequency of polymorphisms between different ethnicities is steadily growing.\u00a0 Recent data suggests that ethnic variations in the expression of allelic variants may result in different pharmacokinetic properties of the anti\u2010cancer medication. In this article, the clinical outcomes of various chemotherapy classes in patients of different ethnicities were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Genetic and nongenetic variables contribute to the interindividual variability in response to chemotherapeutic drugs. Considering pharmacoethnicity in the initial determination of standard chemotherapeutic protocols and treatment algorithms can lead to better clinical outcomes of patients of different ethnicities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.1830","type":"journal-article","created":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T23:44:15Z","timestamp":1683503055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical outcomes of chemotherapy in cancer patients with different ethnicities"],"prefix":"10.1002","volume":"6","author":[{"given":"Suhrud","family":"Pathak","sequence":"first","affiliation":[{"name":"Department of Drug Discovery and Development, Harrison College of Pharmacy Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsee K.","family":"Zajac","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences University of Toledo  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjusha","family":"Annaji","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Development, Harrison College of Pharmacy Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Govindarajulu","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Development, Harrison College of Pharmacy Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi M.","family":"Nadar","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Development, Harrison College of Pharmacy Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Development, Harrison College of Pharmacy Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-2291","authenticated-orcid":false,"given":"R. 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