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The National Comprehensive Cancer Network (NCCN) has published guidelines to aid decision\u2010making about this treatment according to the tumor site, clinical stage, and patient medical status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present review was conducted to identify changes in the NCCN guidelines for glottic cancer treatment made between 2011 and 2022 and to describe the published evidence concerning glottic cancer treatment and oncological outcomes in the same time period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Clinical practice guidelines for head and neck cancer published from 2011 up to 2022 were obtained from the NCCN website (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.nccn.org\">www.NCCN.org<\/jats:ext-link>). Data on glottic cancer treatment recommendations were extracted, and descriptive analysis was performed. In addition, a review of literature registered in the PubMed database was performed to obtain data on glottic cancer management protocols and treatment outcomes from randomized controlled trials, systematic reviews, and meta\u2010analyses published from 2011 to 2022. In total, 24 NCCN guidelines and updates and 68 relevant studies included in the PubMed database were identified. The main guideline changes made pertained to surgical and systemic therapies, the consideration of adverse features, and new options for the treatment of metastatic disease at initial presentation. Early\u2010stage glottic cancer received the most research attention, with transoral endoscopic laser surgery and radiotherapy assessed and compared as the main treatment modalities. Reported associations between treatment types and survival rates for this stage of glottic cancer appear to be similar, but functional outcomes can be highly compromised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NCCN panel members provide updated recommendations based on currently accepted treatment approaches for glottic cancer, constantly reviewing new surgical and non\u2010surgical techniques. The guidelines support decision\u2010making about glottic cancer treatment that should be individualized and prioritize patients' quality of life, functionality, and preferences.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1837","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T06:16:04Z","timestamp":1686204964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Overview of glottic laryngeal cancer treatment recommendation changes in the <scp>NCCN<\/scp> guidelines from 2011 to 2022"],"prefix":"10.1002","volume":"6","author":[{"given":"Lady Paola Aristizabal","family":"Arboleda","sequence":"first","affiliation":[{"name":"Graduate Program A.C. Camargo Cancer Center  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Borburema","family":"Neves","sequence":"additional","affiliation":[{"name":"Graduate Program A.C. 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