{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:13:31Z","timestamp":1783091611564,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Due to sex\u2010specific differences in the incidence and clinical and histopathological characteristics of colorectal cancer (CRC), understanding the impact of sex on CRC may suggest sex\u2010targeted strategies for screening, treatment, and prevention, leading to improved prognosis of CRC. However, there have been few studies investigating the sex\u2010specific differences in CRC in the Republic of Korea. We aimed to assess sex differences in CRC in the Republic of Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, multicenter, cohort study of patients diagnosed with CRC between January 2012 and December 2013 at nine hospitals. Patients who had an uncertain CRC stage, were diagnosed with other cancers within 5\u2009years, had carcinoma in situ, non\u2010epithelial cancer, or primary cancer other than CRC, were excluded. Factors associated with overall survival or progression\u2010free survival were investigated using Cox regression analysis. Cumulative probability of metachronous lesions was compared using the Kaplan\u2013Meier estimator survival analysis and we compared the survival curves of each group using a log\u2010rank test. Outcomes were compared using the chi\u2010square, Fisher's exact, or Student's <jats:italic>t<\/jats:italic>\u2010test, as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three thousand one hundred and forteen patients (1999 men, 1315 women) were included. There was no significant difference in the age at onset between men and women. The proportion of patients diagnosed through regular health check\u2010ups, and asymptomatic at time of diagnosis, was higher in men (48.9% men vs. 42.0% women, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Rectal cancers were more common in men (38.8% men vs. 31.8% women, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Right colon cancers were more common in women (31.4% women vs. 22.7% men, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). <jats:italic>KRAS<\/jats:italic> mutations were found in 109\/317 (34.4%) women and 112\/480 (23.3%) men. Overall CRC survival and progression\u2010free survival were similar in both sexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sex differences in CRC may be due to the biological and social\u2010behavioral differences between the sexes. They should be considered during screening, diagnosis, and treatment of CRC for better outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1845","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T22:17:51Z","timestamp":1687645071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sex\u2010specific differences in colorectal cancer: A multicenter retrospective cohort study"],"prefix":"10.1002","volume":"6","author":[{"given":"Hyun Jin","family":"Joo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Chung\u2010Ang University Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Kyungpook National University Kyungpook National University Hospital  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ik","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yeungnam University College of Medicine  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Bum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Vincent's Hospital, College of Medicine The Catholic University of Korea  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4272-8003","authenticated-orcid":false,"given":"Jae Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kosin University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Gun","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Digestive Research Soonchunhyang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, International St. Mary's Hospital Catholic Kwandong University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chosun University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0039-7728","authenticated-orcid":false,"given":"Bun","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer and Department of Internal Medicine, Research Institute and Hospital National Cancer Center  Goyang Republic of 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