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The highest risk of cardiovascular complications is associated with exposure to anthracyclines and chest radiation. Longitudinal cardiovascular surveillance is recommended for childhood cancer patients; however, the optimal methods and timing are yet to be elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to investigate the feasibility of different echocardiographic methods to evaluate left ventricular systolic function in retrospective datasets, including left ventricular ejection fraction (LVEF), fractional shortening (FS), global longitudinal strain (GLS) and longitudinal strain (LS) as well as the incidence and timing of subclinical left ventricular dysfunction detected by these methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A retrospective longitudinal study was performed with re\u2010analysis of longitudinal echocardiographic data, acquired during treatment and early follow\u2010up, including 41 pediatric sarcoma patients, aged 2.1\u201317.8\u2009years at diagnosis, treated at Astrid Lindgren Children's Hospital, Stockholm, Sweden, during the period 2010\u20132021. All patients had received treatment according to protocols including high cumulative doxorubicin equivalent doses (\u2265250\u2009mg\/m<jats:sup>2<\/jats:sup>). In 68% of all 366 echocardiograms, LS analysis was feasible. Impaired LS values (&lt;17%) was demonstrated in &gt;40%, with concomitant impairment of either LVEF or FS in 20% and combined impairment of both LVEF and FS in &lt;10%. Importantly, there were no cases of abnormal LVEF and FS without concomitant LS impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings demonstrate feasibility of LS in a majority of echocardiograms and a high incidence of impaired LS during anthracycline treatment for childhood sarcoma. We propose inclusion of LS in pediatric echocardiographic surveillance protocols.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1852","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:44:30Z","timestamp":1687657470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Longitudinal strain analysis for assessment of early cardiotoxicity during anthracycline treatment in childhood sarcoma: A single center experience"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2622-5975","authenticated-orcid":false,"given":"Maria Sj\u00f6borg","family":"Alpman","sequence":"first","affiliation":[{"name":"Pediatric Cardiology, Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"},{"name":"Pediatric Oncology, Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annica","family":"Jarting","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristomenis","family":"Manouras","sequence":"additional","affiliation":[{"name":"Department of Cardiology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Inge","family":"Henter","sequence":"additional","affiliation":[{"name":"Pediatric Oncology, Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"},{"name":"Pediatric Oncology, Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta M\u00e5nsson","family":"Broberg","sequence":"additional","affiliation":[{"name":"Pediatric Oncology, Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Cardiology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolas","family":"Herold","sequence":"additional","affiliation":[{"name":"Pediatric Oncology, Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"},{"name":"Pediatric Oncology, Astrid Lindgren Children's Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Childhood Cancer Incidence and Survival in Sweden 1984\u20132010.Report 2013 from the Swedish Childhood Cancer Registry. 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