{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:28:44Z","timestamp":1787657324476,"version":"build-2736575974"},"reference-count":72,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ovarian cancer seriously threatens women's health because of its poor prognosis and high mortality. Due to the lack of efficient early detection and screening methods, when patients seek doctors' help with complaints of abdominal distension, back pain and other nonspecific signs, the clinical results always hint at the widespread metastasis of disease. When referring to the metastasis of this disease, the omentum always takes precedence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Recent findings<\/jats:title><jats:p>The distinguishing feature of the omentum is adipose tissue, which satisfies the energy demand of cancer cells and supplies a more aggressive environment for ovarian cancer cells. In this review, we mainly focus on three important cell types: adipocytes, macrophages, and mesenchymal stem cells. Besides, several mechanisms underlying cancer\u2010associated adipocytes (CAA)\u2010facilitated ovarian cancer cell development have been revealed, including their capacities for storing lipids and endocrine function, and the release of hormones, growth factors, and adipokines. Blocking the reciprocity among cancer cells and various cells located on the omentum might contribute to ovarian cancer therapy. The inhibition of hormones, growth factors and adipokines produced by adipocytes will be a novel therapeutic strategy. However, a sufficient number of trials has not been performed. In spite of this, the therapeutic potential of metformin and the roles of exercise in ovarian cancer will be worth mentioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is almost impossible to overcome completely ovarian cancer at the moment. What we can do is trying our best to improve these patients' prognoses. In this process, adipocytes may bring promising future for the therapy of ovarian cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1858","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T10:09:34Z","timestamp":1692698974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Omentum provides a special cell microenvironment for ovarian cancer"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3181-0375","authenticated-orcid":false,"given":"Zeying","family":"Li","sequence":"first","affiliation":[{"name":"The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6005-9598","authenticated-orcid":false,"given":"Xiaoling","family":"Fang","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixue","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21456"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.11.011"},{"issue":"2","key":"e_1_2_9_4_1","first-page":"98","article-title":"The distribution of secondary growths in cancer of the breast. 1889","volume":"8","author":"Paget S","year":"1989","journal-title":"Cancer Metastasis Rev"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000219"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70201-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-004-0446-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.04.023"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10082117"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16511"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9037197"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127201"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102819"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1999"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04987-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1789"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26396"},{"issue":"1","key":"e_1_2_9_18_1","first-page":"561","article-title":"Leptin contributes to the taxol chemoresistance in epithelial ovarian cancer","volume":"18","author":"Gu F","year":"2019","journal-title":"Oncol Lett"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq276"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5603\/EP.a2018.0081"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041219"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102519"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1018515"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.07.013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040920"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14059751"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers8090079"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1601"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.2.733"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-1090-1"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2589"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.256"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02445-2"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.12.044"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05844"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.08.001"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.09.018"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-017-0093-z"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0445"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25344"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-009-0154-1"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.020"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2221-x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13208"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0329"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0674-9"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804243115"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11150"},{"issue":"10","key":"e_1_2_9_49_1","first-page":"4149","article-title":"miR\u201021 regulates the proliferation and apoptosis of ovarian cancer cells through PTEN\/PI3K\/AKT","volume":"23","author":"Liu HY","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S286639"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21633"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-016-1339-x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203386"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.006"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28335"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191869"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01246-z"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgz083"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.07.020"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081859"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38498"},{"key":"e_1_2_9_62_1","volume-title":"Guidelines for the Diagnosis and Treatment of Ovarian Malignancies","author":"Association G O P C O C a C","year":"2021"},{"key":"e_1_2_9_63_1","unstructured":"China N H C O T P S R O.Guidelines for the Diagnosis and Treatment of Ovarian Cancer; 2022."},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12772"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2012"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133247"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897211027819"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.06.485"},{"key":"e_1_2_9_69_1","first-page":"5229","article-title":"Central adiposity as a major risk factor of ovarian cancer","volume":"29","author":"Delort LKF","year":"2009","journal-title":"Anticancer Res"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.08.018"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002966511100320X"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0706"},{"issue":"10","key":"e_1_2_9_73_1","first-page":"5045","article-title":"Effect of exercise on peritoneal microenvironment and progression of ovarian cancer","volume":"11","author":"Morrisson MJ","year":"2021","journal-title":"Am J Cancer Res"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T03:33:35Z","timestamp":1698204815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":72,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/cnr2.1858"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1858","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,21]]},"assertion":[{"value":"2023-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1858"}}