{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:55:59Z","timestamp":1776084959311,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010246","name":"Postdoctoral Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neuroblastoma is a common malignant tumor stemming from the sympathetic nervous system in children, which is often life\u2010threatening. The genetics of neuroblastoma remains unclear. Studies have shown that miRNAs participate in the regulation of a broad spectrum of biological pathways. The abnormity in the miRNA is associated with the risk of various cancers, including neuroblastoma. However, research on the relationship of miRNA polymorphisms with neuroblastoma susceptibility is still in the initial stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this research, a retrospective case\u2013control study was conducted to explore whether <jats:italic>miR\u2010100<\/jats:italic> rs1834306 A\u2009&gt;\u2009G polymorphism is associated with neuroblastoma susceptibility. We enrolled 402 cases and 473 controls for the study. The logistic regression analysis was adopted to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between <jats:italic>miR\u2010100<\/jats:italic> rs1834306 A\u2009&gt;\u2009G and neuroblastoma risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results elucidated that the <jats:italic>miR\u2010100<\/jats:italic> rs1834306 A\u2009&gt;\u2009G polymorphism was associated with the decreased risk of neuroblastoma (AG versus AA: adjusted OR\u2009=\u20090.72, 95% CI\u2009=\u20090.53\u20130.98, and <jats:italic>P<\/jats:italic>\u2009=\u20090.038). The subsequent stratified analysis further found that rs1834306 AG\/GG genotype reduced the risk of neuroblastoma in the subgroup with tumors of the mediastinum origin (adjusted OR\u2009=\u20090.63, 95% CI\u2009=\u20090.41\u20130.95, and <jats:italic>P<\/jats:italic>\u2009=\u20090.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, <jats:italic>miR\u2010100<\/jats:italic> rs1834306 A\u2009&gt;\u2009G polymorphism was shown to associate with decreased neuroblastoma risk in Chinese children, especially for neuroblastoma of mediastinum origin. This conclusion needs to be verified in additional large\u2010size case\u2013control studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1875","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T10:54:19Z","timestamp":1690541659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i><scp>miR<\/scp>\u2010100<\/i> rs1834306 a\u2009&gt;\u2009G polymorphism decreases neuroblastoma risk in Chinese children"],"prefix":"10.1002","volume":"6","author":[{"given":"Yufeng","family":"Han","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health  Guangzhou Guangdong 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Biobank Harbin Medical University Cancer Hospital  Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-2892","authenticated-orcid":false,"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics, 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