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Ph\u2010like B\u2010ALL patients lack the <jats:italic>BCR::ABL1<\/jats:italic> translocation but share gene expression profiles with Ph+\u2009B\u2010ALL. The role of TKIs for Ph\u2010like patients pre\u2010 and post\u2010hematopoietic stem cell transplantation (HSCT) is not yet clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>Here we present five cases of pediatric, adolescent, and young adult patients who presented with Ph\u2010like B\u2010ALL or CML in B\u2010ALL blast phase who were treated with personalized TKI regimens pre\u2010 and post\u2010HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report describes several novel Ph\u2010like fusions as well as combinations of TKIs with chemotherapy or immunotherapy not yet reported in the pediatric population. This case series provides real\u2010world experience highlighting the potential application of pre\u2010 and post\u2010HSCT use of TKIs in a subset of patients with targetable fusions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1901","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T12:17:41Z","timestamp":1699359461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pre\u2010and <scp>post\u2010HSCT<\/scp> use of <scp>TKI<\/scp> therapy for fusion\u2010driven <scp>B\u2010ALL<\/scp>: A case series of five pediatric, adolescent and young adult patients"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-8210","authenticated-orcid":false,"given":"Savannah S.","family":"Shumock","sequence":"first","affiliation":[{"name":"School of Medicine University of California, San Francisco  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-2703","authenticated-orcid":false,"given":"William C.","family":"Temple","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Benioff Children's Hospitals, University of California, San Francisco  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8600-6400","authenticated-orcid":false,"given":"Amanda","family":"Marinoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Benioff Children's Hospitals, University of California, San Francisco  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Aaronson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Benioff Children's Hospitals, University of California, San Francisco  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Southworth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Benioff Children's Hospitals, University of California, San Francisco  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simayijiang","family":"Xirenayi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Benioff Children's Hospitals, University of California, San Francisco  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex G.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Benioff Children's Hospitals, University of California, San Francisco  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley G.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Benioff Children's Hospitals, University of California, San Francisco  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-9351","authenticated-orcid":false,"given":"E. 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