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The current study aims to evaluate the possibility of <jats:italic>Toxoplasma gondii<\/jats:italic> (<jats:italic>T. gondii<\/jats:italic>) as a probable treatment for cancers such as melanoma, breast, ovarian, lung, and pancreatic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Recent findings<\/jats:title><jats:p>Nonreplicating type I uracil auxotrophic mutants of <jats:italic>T. gondii<\/jats:italic> can stimulate immune responses against tumors by reverse immunosuppression at the cellular level. <jats:italic>T. gondii<\/jats:italic> can be utilized to research T helper 1 (Th1) cell immunity in intracellular infections. Avirulent <jats:italic>T. gondii<\/jats:italic> uracil auxotroph vaccine can change the tumor's immunosuppression and improve the production of type 1 helper cell cytokines, i.e., Interferon\u2010gamma (IFN\u2010\u03b3) and Interleukin\u201012 (IL\u201012) and activate tumor\u2010related Cluster of Differentiation 8 (CD8+) T cells to identify and destroy cancer cells. The <jats:italic>T. gondii<\/jats:italic> profilin protein, along with <jats:italic>T. gondii<\/jats:italic> secreted proteins, have been found to exhibit promising properties in the treatment of various cancers. These proteins are being studied for their potential to inhibit tumor growth and enhance the effectiveness of cancer therapies. Their unique mechanisms of action make them valuable candidates for targeted interventions in ovarian cancer, breast cancer, pancreatic cancer, melanoma, and lung cancer treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, the study underscores the significant potential of harnessing <jats:italic>T. gondii<\/jats:italic>, including its diverse array of proteins and antigens, particularly in its avirulent form, as a groundbreaking approach in cancer immunotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1963","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:26:25Z","timestamp":1702945585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A potential cure for tumor\u2010associated immunosuppression by <scp><i>Toxoplasma 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