{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:17Z","timestamp":1753868657784,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anaplastic lymphoma kinase (<jats:italic>ALK<\/jats:italic>)\u2010positive lung cancer has a better long\u2010term prognosis with <jats:italic>ALK<\/jats:italic>\u2010inhibitor than other lung cancers. However, resistance to <jats:italic>ALK<\/jats:italic>\u2010inhibitors and the control of metastases in the central nervous system (CNS) remain to be a challenge in the management of <jats:italic>ALK<\/jats:italic>\u2010positive lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We present the case of a 23\u2010year\u2010old man who developed multiple brain metastases while receiving alectinib treatment for <jats:italic>ALK<\/jats:italic>\u2010positive lung cancer. After 3\u2009months of lorlatinib initiation, brain metastases disappeared, and complete response (CR) was maintained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While lorlatinib can be used as first line therapy, this drug may be considered as second line or later option for patients with multiple brain metastases if the patient has already been treated with other <jats:italic>ALK<\/jats:italic>\u2010inhibitors since lorlatinib is thought to have good CNS penetration. This treatment option should be verified by further research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1981","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T05:06:10Z","timestamp":1705035970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful application of lorlatinib in a 23\u2010year\u2010old patient with anaplastic lymphoma kinase (<scp><i>ALK)<\/i>\u2010positive<\/scp> lung cancer and multiple brain metastases"],"prefix":"10.1002","volume":"7","author":[{"given":"Yosuke","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Sendai Kousei Hospital  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9824-6572","authenticated-orcid":false,"given":"Yosuke","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sendai Kousei Hospital  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Iwate Prefectural Central Hospital  Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichiro","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sendai Kousei Hospital  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sendai Kousei Hospital  Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Doman","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sendai Kousei Hospital  Miyagi 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