{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:17Z","timestamp":1753868657159,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["81372674"],"award-info":[{"award-number":["81372674"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical resection remains the primary treatment option for gallbladder carcinoma (GBC). However, there is a pressing demand for prognostic tools that can refine patients' treatment choices and tailor personalized therapies accordingly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The nomograms were constructed using the data of a training cohort (<jats:italic>n<\/jats:italic> =\u2009378) of GBC patients at Eastern Hepatobiliary Surgery Hospital (EHBH) between 2008 and 2018. The model's performance was validated in GBC patients (<jats:italic>n<\/jats:italic> =\u2009108) at Guangzhou Centre from 2007 to 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The 5\u2010year overall survival (OS) rate in the training cohort was 24.4%. Multivariate analyses were performed using preoperative and postoperative data to identify independent predictors of OS. These predictors were then incorporated into preoperative and postoperative nomograms, respectively. The C\u2010index of the preoperative nomogram was 0.661 (95% CI, 0.627 to 0.694) for OS prediction and correctly delineated four subgroups (5\u2010year OS rates: 48.1%, 19.0%, 15.6%, and 8.1%, <jats:italic>p<\/jats:italic> &lt;\u20090.001). The C\u2010index of the postoperative nomogram was 0.778 (95%CI, 0.756 \u20130.800). Furthermore, this nomogram was superior to the 8th TNM system in both C\u2010index and the net benefit on decision curve analysis. The results were externally validated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The two nomograms showed an optimally prognostic prediction in GBC patients after curative\u2010intent resection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1991","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T11:19:29Z","timestamp":1709637569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nomograms to predict long\u2010term survival for patients with gallbladder carcinoma after resection"],"prefix":"10.1002","volume":"7","author":[{"given":"Shilei","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Hepatic Surgery II The Eastern Hepatobiliary Surgery Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biliary Surgery IV The Eastern Hepatobiliary Surgery Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiliang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Sun Yat\u2010Sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery II The Eastern Hepatobiliary Surgery Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery II The Eastern Hepatobiliary Surgery Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery II The Eastern Hepatobiliary Surgery Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery The Fifth Clinical Medical College of Henan University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijian","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Vascular Surgery The Chenggong Hospital, Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-3796","authenticated-orcid":false,"given":"Baohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biliary Surgery IV The Eastern Hepatobiliary Surgery Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0201"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1479-666X(08)80073-X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-10-87"},{"volume-title":"AJCC Cancer Staging Manual","year":"2017","author":"Cancer AJCC","key":"e_1_2_11_5_1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182703409"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001339"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw063"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.212"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71116-7"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.7934"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.5066"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.2220"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-652"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12444"},{"key":"e_1_2_11_16_1","unstructured":"FrankE.HJHHM. R Package version 3.9\u20132.http:\/\/CRAN.R-project.org\/package=Hmisc"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.9791"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.37"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X06295361"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200010000-00011"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1479-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10401"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3011-y"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.10.014"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i45.5167"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5243-y"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0899-1"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.02.006"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02544-y"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.14701\/kjhbps.2014.18.4.129"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2017.06.011"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.1991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T12:52:03Z","timestamp":1711630323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.1991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/cnr2.1991"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.1991","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1991"}}