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Hypoglycemia can be attributed to paraneoplastic secretion of \u201cBig\u2010IGF\u2010II,\u201d a precursor of Insulin\u2010like growth factor\u2010II. This prohormone aberrantly binds to and activates insulin receptors, with consecutive initiation of common insulin actions such as inhibition of gluconeogenesis, activation of glycolysis and stimulation of cellular glucose uptake culminating in recurrent tumor\u2010induced hypoglycemic episodes. Complete tumor resection or debulking surgery is considered the most promising treatment for DPS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>Here, we report a rare case of a recurrent Doege\u2010Poter Syndrome with atypical gelatinous tumor lesions of the lung, pleura and pericardial fat tissue in an 87\u2010year\u2010old woman. Although previously described as ineffective, we propose that adjuvant treatment with Octreotide in conjunction with intravenous glucose helped to maintain tolerable blood glucose levels before tumor resection. The somatostatin\u2010analogue Lanreotide was successfully used after tumor debulking surgery (R2\u2010resection) to maintain adequate blood glucose control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that somatostatin\u2010analogues bear the potential of being effective in conjunction with limited surgical approaches for the treatment of hypoglycemia in recurrent or non\u2010totally resectable SFT entities underlying DPS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.1992","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T11:23:35Z","timestamp":1709637815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effective management of recurrent Doege\u2013Potter syndrome with somatostatin\u2010analogues: A case report"],"prefix":"10.1002","volume":"7","author":[{"given":"Felix","family":"Sch\u00f6ler","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine II, University Hospital of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3277-0301","authenticated-orcid":false,"given":"Maximilian Andreas","family":"Storz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine II, University Hospital of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Department of Internal Medicine II, Center for Complementary Medicine, University Hospital of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashkan","family":"Khavaran","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine II, University Hospital of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"H\u00fcmmler","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center University Hospital of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian Frederik","family":"Russe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinic for Diagnostic and Interventional Radiology, University Hospital of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph\u2010Ferdinand","family":"Wielenberg","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Freiburg Faculty of Medicine  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Laubner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine II, University Hospital of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Seufert","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine II, University Hospital of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","first-page":"955","article-title":"Fibro\u2010SARCOMA of the mediastinum","volume":"92","author":"Doege KW","year":"1930","journal-title":"Ann Surg"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/14.1.60"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007417"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(00)70242-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"Lopez\u2010HinostrozaM SalazarJM D\u00e1vilaJ AbsencioAY Contreras\u2010PulacheH.Doege\u2013Potter Syndrome due to Endothoracic Solitary Hypoglycemic Fibrous Tumor; 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