{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:08:24Z","timestamp":1785276504964,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anastrozole is a selective aromatase inhibitor used for the treatment of postmenopausal hormone\u2010sensitive breast cancer. The major side effects include osteoporosis, hypercholesterolemia, and musculoskeletal events, such as arthralgia and myalgia. Other adverse events are rare, including symptoms of acne, masculinization, and drug\u2010induced liver injury, with the latter reported in a few cases only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>Here, we report on a patient under anastrozole therapy who developed drug\u2010induced liver injury as assessed by the updated Roussel Uclaf Causality Assessment Method 5\u2009weeks after a mild SARS\u2010CoV\u20102 infection, which is, to the best of our knowledge, the first report of its kind involving anastrozole. Discontinuation of anastrozole resulted in a marked improvement of the alanine aminotransaminase, and aspartate aminotransaminase as well as normalized lactate dehydrogenase serum levels already seen after 26\u2009days. Surprisingly, however, the cholestatic serum markers gamma\u2010glutamyl transpeptidase and alkaline phosphatase showed a further rise, and took another 4\u2009weeks to drop significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presentation of this case is meant to alert physicians to a potential drug\u2010induced liver injury following mild SARS\u2010CoV\u20102 infection in patients under anastrozole medication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2028","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T09:44:41Z","timestamp":1712310281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Drug\u2010induced liver injury as assessed by the updated <scp>Roussel Uclaf Causality Assessment Method<\/scp> following mild <scp>COVID\u201019<\/scp> in a patient under anastrozole therapy\u2014A case report"],"prefix":"10.1002","volume":"7","author":[{"given":"Wolfgang","family":"Lischka","sequence":"first","affiliation":[{"name":"Private Practice  Gumpoldskirchen Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2768-795X","authenticated-orcid":false,"given":"Gernot","family":"Kriegsh\u00e4user","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Yerevan State Medical University  Yerevan Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-008-0071-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2009.12.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000243868.64078.af"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60017-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-32"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Drug\u2010induced LI after switching from tamoxifen to anastrozole in a patient with a history of breast cancer being treated for hypertension and diabetes","volume":"11","author":"Potme\u0161il P","year":"2021","journal-title":"Ther Adv Chronic Dis"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31404"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000000319"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v12.i2.109"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i2.257"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13590"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326792"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i2.472"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.09.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094828"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07230-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.642922"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.2028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T03:35:09Z","timestamp":1714102509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.2028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/cnr2.2028"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.2028","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2028"}}