{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:36:40Z","timestamp":1764333400455,"version":"3.41.2"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non\u2010coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>International databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA. After screening by title\/abstract and full\u2010text, necessary data were extracted. Random\u2010effect meta\u2010analysis was performed for pooling the areas under the curve (AUCs), specificity, and sensitivity of lncRNAs for the diagnosis of CCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 33 studies were chosen to be included in the final analysis, comprised of 2677 patients. Meta\u2010analysis of AUCs for evaluation of CCA resulted in pooled AUC of 0.79 (95% CI: 0.75\u20130.82; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200969.11, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Additionally, overall sensitivity of 0.80 (95% CI 0.75\u20130.84) and specificity of 0.77 (95% CI: 0.68\u20130.84) were observed. Measurement of lncRANs in the assessment of CCA also improved overall survival significantly (effect size 1.61, 95% CI: 1.39\u20131.82). A similar result was found for progression\u2010free survival (effect size 1.57, 95% CI: 1.20\u20131.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on our findings, lncRNAs showed promising results as biomarkers in the diagnosis of CCA since they had acceptable sensitivity and specificity, in addition to the fact that improved survival in this poor prognosis cancer. Further studies might be needed to address this issue and find the best clinically useful lncRNA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2029","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T15:19:30Z","timestamp":1711120770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of long non\u2010coding <scp>RNAs<\/scp> in cholangiocarcinoma: A systematic review and <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1002","volume":"7","author":[{"given":"Parnian","family":"Shobeiri","sequence":"first","affiliation":[{"name":"School of medicine Tehran University of Medical Sciences  Tehran Iran"},{"name":"Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran  Iran"},{"name":"Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center Tehran University of 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