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MB originates from neural precursor cells in distinctive regions of the rhombic lip, and their maturation occurs in the cerebellum or the brain stem during embryonal development. Also, apoptosis is a programmed cell death associated with numerous physiological as well as pathological regulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Recent Findings<\/jats:title><jats:p>Irradiation (IR)\u2010induce apoptosis triggers cell death, with or without intervening mitosis within a few hours of IR and these share different morphologic alteration such as, loss of normal nuclear structure as well as degradation of DNA. Moreover, MB is strikingly sensitive to DNA\u2010damaging therapies and the role of apoptosis a key treatment modality. Furthermore, in MB, the apoptotic pathways are made up of several triggers, modulators, as well as effectors. Notably, IR\u2010induced apoptotic mechanisms in MB therapy are very complex and they either induce radiosensitivity or inhibit radioresistance leading to potential effective treatment strategies for MB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review explicitly explores the pivotal roles of IR\u2010induced apoptosis in the pathogenesis and therapy of MB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2048","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T01:20:52Z","timestamp":1712798452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The pivotal role of irradiation\u2010induced apoptosis in the pathogenesis and therapy of medulloblastoma"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0363","authenticated-orcid":false,"given":"Seidu 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