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Isotypes, magnitude, and the effector functions of antibodies produced by the B cells within the tumor environment differ among cancer types. Interestingly, apart from binding with specific tumor antigens, antibodies produced by tumor\u2010infiltrating B cells could bind to some non\u2010specific receptors, peculiarly expressed by cancer cells. Antibody\u2010based immunotherapies have revolutionized the modalities of cancer treatment across the world but are still limited against hematological malignancies and a few types of solid tumor cancers with a restricted number of targets, which necessitates the expansion of the field to have newer effective targeted antibody therapeutics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Here, we discuss about recent understanding of the protective spontaneous antitumor humoral responses in human cancers, with an emphasis on the advancement and future perspectives of antibody\u2010based immunotherapies in cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2056","type":"journal-article","created":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T14:14:19Z","timestamp":1711289659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["B cell responses and antibody\u2010based therapeutic 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