{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:48:34Z","timestamp":1781876914276,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH\u2010YM1120101"],"award-info":[{"award-number":["TCVGH\u2010YM1120101"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 111\u20102314\u2010B\u2010075A\u2010007"],"award-info":[{"award-number":["NSTC 111\u20102314\u2010B\u2010075A\u2010007"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Haploidentical hematopoietic stem cell transplantation (haplo\u2010HSCT) has emerged as an effective approach for acute leukemia, primarily due to the inherent difficulty in finding human leukocyte antigen\u2010matched unrelated donors (MUD). Nevertheless, it remains uncertain whether haplo\u2010HSCT and MUD\u2010HSCT can provide comparable outcomes in patients with acute leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to assess the overall survival (OS) and leukemia\u2010free survival (LFS) outcomes between the MUD\u2010HSCT and haplo\u2010HSCT groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>This retrospective analysis encompassed adult patients with acute leukemia undergoing the initial allo\u2010HSCT. Among these 85 patients, we stratified 33 patients into the MUD\u2010HSCT group and 52 to the haplo\u2010HSCT group. The primary outcomes were OS and LFS. The median OS was not reached in the haplo\u2010HSCT group, while it reached 29.8\u2009months in patients undergoing MUD\u2010HSCT (<jats:italic>p<\/jats:italic>\u2009=\u2009.211). Likewise, the median LFS periods were 52.6\u2009months in the haplo\u2010HSCT group and 12.7\u2009months in the MUD\u2010HSCT group (<jats:italic>p<\/jats:italic>\u2009=\u2009.212). Importantly, neither the OS nor LFS showed substantial differences between the MUD\u2010HSCT and haplo\u2010HSCT groups. Furthermore, univariate analyses revealed that haplo\u2010HSCT did not demonstrate a significantly higher risk of worse LFS (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.38\u20131.25; <jats:italic>p<\/jats:italic>\u2009=\u2009.216) or OS (HR, 0.67; 95% CI, 0.36\u20131.26; <jats:italic>p<\/jats:italic>\u2009=\u2009.214) than MUD\u2010HSCT. Notably, a high European Group for Blood and Marrow Transplantation risk score (HR, 1.44; 95% CI, 1.10\u20131.87; <jats:italic>p<\/jats:italic>\u2009=\u2009.007) and non\u2010complete remission (HR, 2.48; 95% CI, 1.17\u20135.23; <jats:italic>p<\/jats:italic>\u2009=\u2009.017) were significantly correlated with worse OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Haplo\u2010HSCT may serve as an alternative to MUD\u2010HSCT for the treatment of acute leukemia, offering similar survival outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2060","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T02:44:54Z","timestamp":1712803494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Haploidentical and matched unrelated donor allogeneic hematopoietic stem cell transplantation offer similar survival outcomes for acute leukemia"],"prefix":"10.1002","volume":"7","author":[{"given":"Yin\u2010Che","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Lun","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh\u2010Pyng","family":"Gau","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Taipei Medical University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-0368","authenticated-orcid":false,"given":"Chieh\u2010Lin Jerry","family":"Teng","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Department of Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"},{"name":"Ph.D. Program in Translational Medicine National Chung Hsing University  Taichung Taiwan"},{"name":"Rong Hsing Research Center for Translational Medicine National Chung Hsing University  Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.813"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899\u2010017\u20100371\u20104"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017\u20100009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1311707"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13096"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102003\u201002\u20100430"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1997.15.5.1767"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.189258"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620721998124"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.03.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2016002196"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201004\u2010639831"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.217"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2016.0225"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201008\u2010733196"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(19)33018\u20101"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.110"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201003\u2010418202"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.03.003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010022\u201001574\u20100"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2215943"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.07.010"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010018\u20100598\u20100"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24677"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221078466"}],"container-title":["Cancer 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