{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:43:39Z","timestamp":1784951019166,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An elevated neutrophil\u2010to\u2010lymphocyte ratio (NLR) in peripheral blood is an independent prognostic indicator of various cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we aimed to investigate the prognostic relevance of the intratumoral immune cell balance in gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The study included 82 patients who underwent curative resection for gastric cancer. The intratumoral cluster of differentiation (CD) 15\u2010 and CD8\u2010positive cells were evaluated using immunohistochemical staining. Additionally, clinicopathological factors and prognoses were analyzed. Patients with high intratumoral CD15\/CD8 ratios had significantly lower overall survival (OS) and relapse\u2010free survival (RFS) compared to those with low CD15\/CD8 ratios (<jats:italic>p<\/jats:italic>\u2009=\u2009.0026 and <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001, respectively). Additionally, a high CD15\/CD8 ratio was associated with lymph node metastasis (<jats:italic>p<\/jats:italic>\u2009=\u2009.019). Patients with high NLR had a significantly lower RFS than those with low NLR (<jats:italic>p<\/jats:italic>\u2009=\u2009.0050). Multivariate analysis revealed that the intratumoral CD15\/CD8 ratio, NLR, and venous invasion were independent prognostic indicators of RFS (CD15\/CD8 ratio: <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, hazard ratio (HR)\u2009=\u200914.7, 95% confidence interval (CI)\u2009=\u20093.8\u201356.8; NLR: <jats:italic>p<\/jats:italic>\u2009=\u2009.010, HR\u2009=\u20095.4, 95% CI\u2009=\u20091.5\u201319.6; venous invasion: <jats:italic>p<\/jats:italic>\u2009=\u2009.005, HR\u2009=\u20097.4, 95% CI\u2009=\u20091.8\u201329.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, we found that the intratumoral CD15\/CD8 ratio is an independent prognostic factor following gastric cancer resection and its increase is associated with lymph node metastasis and microscopic lymph vessel invasion. Immunological evaluation with additional aspects of innate immunity may be useful in predicting cancer prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2099","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T03:03:06Z","timestamp":1717556586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The ratio of intratumoral <scp>CD15<\/scp><sup>+<\/sup> neutrophils to <scp>CD8<\/scp><sup>+<\/sup> lymphocytes predicts recurrence in patients with gastric cancer after curative resection"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4917-8948","authenticated-orcid":false,"given":"Junichiro","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Fukushima Medical University  Fukushima City 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University  Fukushima City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhide","family":"Ishigame","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Fukushima Medical University  Fukushima City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Fukushima Medical University  Fukushima City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kenjo","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Fukushima Medical University  Fukushima City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Tract Surgery Fukushima Medical University  Fukushima City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Marubashi","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Fukushima Medical University  Fukushima City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3909"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16414"},{"key":"e_1_2_11_6_1","first-page":"385","article-title":"The presence of tumour\u2010infiltrating neutrophils is an independent adverse prognostic feature in clear cell renal cell 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