{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:05:11Z","timestamp":1772118311569,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972280"],"award-info":[{"award-number":["81972280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972290"],"award-info":[{"award-number":["81972290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1452300"],"award-info":[{"award-number":["23ZR1452300"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The presence of cancer cachexia is a significant adverse prognostic indicator in patients with malignant tumors. Cancer cachexia is a multifactorial syndrome characterized by a constant loss of skeletal muscles with or without a loss of weight, leading to immune dysfunction. We performed a retrospective study to investigate the influence of cachexia on the immunotherapy efficacy and prognosis for malignant tumors of the digestive system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study adopts a cross\u2010sectional design. The prognosis data of patients with advanced cancer of the digestive system who received immunotherapy from September 2021 to December 2022 were analyzed. Cachexia was calculated using the change of the area of the psoas major muscle (PMMA) or the weight. We measured the change at the beginning of immunotherapy and at least 2\u2009cycles afterward. The participants were categorized into the cachexia group and control group based on the evaluation criteria. Kaplan\u2013Meier and Log\u2010rank methods were used for survival analysis. Cox proportional hazard model as a method to assess the contribution of different clinical factors to overall survival (OS) and progression\u2010free survival (PFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total number of 98 patients, including esophageal carcinoma (4, 4%), gastric (36, 37%), colorectal (51, 52%), and other cancer types (7, 7%), were enrolled. Fifty\u2010four patients were diagnosed with non\u2010cancer cachexia, and the cancer cachexia group included 44 patients. The median PFS in the cachexia group was shorter than that in the control group (130\u2009days vs. 212\u2009days). Their difference was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.321). The survival rate of the patients without cachexia was longer than of those with cachexia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.027). The level of albumin and the number of metastatic organs were related to PFS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.020,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.029). The albumin level was significantly associated with the OS of patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The presence of cachexia was significantly associated with poor OS in patients with malignant tumors of the digestive system who received immunotherapy, not with PFS or the response to immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.2100","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T06:45:22Z","timestamp":1716360322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of cachexia on immunotherapy efficacy and prognosis for malignant tumors of the digestive system"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-4475","authenticated-orcid":false,"given":"Zhirui","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Oncology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai East Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(19)32319\u20100"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010020\u20100488\u20106"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12766"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010020\u20106583\u20103"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201745172"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2019.03.006"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14734"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5522"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12755"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201018\u20101847"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smhs.2020.10.003"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12698"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480520"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13505"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262\u2010021\u201002997\u20102"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12761"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13061980"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605578"},{"issue":"8","key":"e_1_2_13_24_1","first-page":"3538","article-title":"Cancer cachexia syndrome and clinical outcome in patients with metastatic. 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