{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:55:26Z","timestamp":1778504126967,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reduced ovarian reserve is among the crucial long\u2010term side effects of using chemotherapy agents in breast cancer, yielding early ovarian failure. On the other hand, vitamin D is an essential factor in protecting the follicles and an important predictive factor for successful IVF therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is evaluation of vitamin D as a agent that can reduce fertility complications of chemotherapy specially in young women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Breast cancer patients undergoing chemotherapy at two cancer institutes were enrolled in this study. The case group received 1000\u2009IU of calcitriol, and the AMH level was measured at the baseline, after chemotherapy, and six months after chemotherapy. The primary end point was improvement in the AMH level after six months of chemotherapy. the secondary endpoint was to evaluate the predictive factors of AMH level decline during chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2018 and 2019, 18 and 15 patients were enrolled in the case and control groups, respectively. The mean AMH level (ngr\/ml) of the patients in the case and control group were 3.16 and 2.37\u2009ng\/mL, respectively (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.16). These levels were 0.387 and 0.19 after six months (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.38). The AMH rise immediately after chemotherapy cycles to six months after chemotherapy, in the case and control groups were 0.86 and 0.44\u2009ng\/mL, respectively, which was slightly higher in the case group but not statistically significant between two groups (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u2009.054).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite a minimal rise in the AMH level after six months of chemotherapy, the study could not demonstrate any protective effect of vitamin D on patients' ovarian reserve undergoing chemotherapy for breast cancer. Further larger studies are needed to evaluate the effect of vitamin D supplements on ovarian reserve beside optimal dose and duration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2104","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:55:08Z","timestamp":1719226508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The protective effect of vitamin D on ovarian reserve and <scp>anti\u2010mullerian<\/scp> hormone in patients undergoing chemotherapy for breast cancer, a randomized phase <scp>\u0399\u0399<\/scp> clinical trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Zahra","family":"Dastmardi","sequence":"first","affiliation":[{"name":"Radiation Oncology Research Center, Cancer Research Institute Iran Cancer institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Radiation Oncology Tehran University of Medical Sciences  Tehran 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Cancer Research Institute Iran Cancer institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Radiation Oncology Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadaf","family":"Alipour","sequence":"additional","affiliation":[{"name":"Breast Disease Research Centre (BDRC), Arash Women's Hospital Tehran University of Medical Sciences  Tehran 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