{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:25:18Z","timestamp":1785871518071,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Plasmacytoma of the skull base is a rare manifestation of plasma cell neoplasm with only a few cases documented in literature involving young adults. Plasmacytoma can be an isolated solitary lesion or a secondary manifestation of multiple myeloma (MM). In this study, we report the clinical and radiological characteristics, management, and outcomes of patients under the age of 40 who presented with skull base plasmacytoma and associated neurological manifestations. Additionally, we share our experience in treating a rare case of skull base plasmacytoma diagnosed during pregnancy, in which the patient exhibited a favorable response to myeloma treatment initiated after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Series<\/jats:title><jats:p>Four patients were identified, comprising one pregnant female and three male patients, with a median age of 36\u2009years (range 33\u201337\u2009years). The main presenting symptoms were headache, dizziness, and cranial nerve palsy. All patients received underwent systemic myeloma therapy and radiotherapy with three patients also underwent autologous stem cell transplantation (ASCT). Notably, all patients achieved complete remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Skull base plasmacytoma represents a rare manifestation of plasma cell neoplasms, underscoring the importance of considering it in the differential diagnosis of skull base lesions to ensure early intervention and avoid potential serious complications. Throughout our series, the cornerstone of therapy involved radiotherapy, systemic myeloma therapy, and ASCT, all of which elicited a favorable response in every case.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2106","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T10:00:07Z","timestamp":1720173607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Skull base plasmacytoma in young patients aged below 40\u2009years: Radiological perspectives and clinical outcomes"],"prefix":"10.1002","volume":"7","author":[{"given":"Hesham","family":"Elsabah","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medical Oncology National Center for Cancer Care &amp; Research (NCCCR), Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-8831","authenticated-orcid":false,"given":"Rola","family":"Ghasoub","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National Center for Cancer Care &amp; Research (NCCCR), Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina S.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology National Center for Cancer Care &amp; Research (NCCCR), Hamad Medical Corporation (HMC)  Doha Qatar"},{"name":"Department of Laboratory Medicine and Pathology Weill Cornell Medical College (WCMC\u2010Q)  Doha Qatar"},{"name":"Department of Clinical Pathology National Cancer Institute  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feryal","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology National Center for Cancer Care &amp; Research (NCCCR), Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood B.","family":"Aldapt","sequence":"additional","affiliation":[{"name":"Internal Medicine Unity hospital, Rochester Regional Health  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruba Y.","family":"Taha","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medical Oncology National Center for Cancer Care &amp; 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Research (NCCCR), Hamad Medical Corporation (HMC)  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honar","family":"Cherif","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medical Oncology National Center for Cancer Care &amp; Research (NCCCR), Hamad Medical Corporation (HMC)  Doha Qatar"},{"name":"Faculty of Medicine College of Medicine, Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.6.2037"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_159009"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009313"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010016\u20103015\u20105"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100035\u20101560047"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102003\u201043327"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102002\u201031570\u20101"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.2073"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.6958"},{"key":"e_1_2_14_11_1","unstructured":"The United Nations \u2010 Department of Economic and Social Affairs.Compare Median Age of Qatar vs Western Europe | database. earth."},{"key":"e_1_2_14_12_1","volume-title":"Multiple Myeloma","author":"NCCN Clinical Practice Guidelines in Oncology","year":"2023"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.11.020"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406207211066173"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21876"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224\u2010019\u201001296\u20102"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14291"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010017\u20100549\u20101"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.2106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T17:45:56Z","timestamp":1722015956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.2106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/cnr2.2106"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.2106","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2106"}}